TGF‐β1‐PML SUMOylation‐peptidyl‐prolyl cis–trans isomerase NIMA‐interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis
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DOI: 10.1002/jcp.27357
Abstract: Transforming growth factor‐β (TGF‐β) signaling pathway is involved in fibrosis in most, if not all forms of cardiac diseases. Here, we evaluate a positive feedback signaling the loop of TGF‐β1/promyelocytic leukemia (PML) SUMOylation/Pin1 promoting the… read more here.
Keywords: positive feedback; fibrosis; tgf; pml ... See more keywords
RING tetramerization is required for nuclear body biogenesis and PML sumoylation
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DOI: 10.1038/s41467-018-03498-0
Abstract: ProMyelocyticLeukemia nuclear bodies (PML NBs) are stress-regulated domains directly implicated in acute promyelocytic leukemia eradication. Most TRIM family members bind ubiquitin E2s and many acquire ligase activity upon RING dimerization. In contrast, PML binds UBC9, the… read more here.
Keywords: nuclear body; pml; pml sumoylation; ring tetramerization ... See more keywords