Eliminating METTL1‐mediated accumulation of PMN‐MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32585
Abstract: Background and Aims: Radiofrequency ablation (RFA) is an important curative therapy in hepatocellular carcinoma (HCC), but recurrence rate remains as high as all the other HCC therapeutic modalities. Methyltransferase 1 (METTL1), an enzyme for m7G… read more here.
Keywords: rfa; accumulation; pmn mdscs; recurrence ... See more keywords
Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.12.027
Abstract: Myeloid-derived suppressor cells (MDSCs) play a major role in cancer progression. In this study, we investigated the mechanisms by which complement C5a increases the capacity of polymorphonuclear MDSCs (PMN-MDSCs) to promote tumor growth and metastatic… read more here.
Keywords: cancer; pmn mdscs; metastasis; c5a ... See more keywords
Impaired myeloid-derived suppressor cells are associated with recurrent implantation failure: A case-control study.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2021.103316
Abstract: BACKGROUND Studies have reported that myeloid-derived suppressor cells (MDSCs) contribute to maintain pregnancy. The aim of this case-control study was to test whether there is a dysregulation of peripheral MDSCs in recurrent implantation failure (RIF).… read more here.
Keywords: suppressor cells; derived suppressor; mdscs; pmn mdscs ... See more keywords
The roles of polymorphonuclear myeloid-derived suppressor cells in endometriosis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2021.103371
Abstract: OBJECTIVES This study aimed to determine the systemic and local proportions, focal localization, and characteristics of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in endometriosis. STUDY DESIGN Peripheral blood and peritoneal fluid were obtained from patients with… read more here.
Keywords: endometriosis; derived suppressor; pmn mdscs; polymorphonuclear myeloid ... See more keywords
ANKRD22 is a potential novel target for reversing the immunosuppressive effects of PMN-MDSCs in ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005527
Abstract: Background Ovarian cancer is the deadliest type of malignant gynecological tumor. Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are involved ovarian cancer and are closely related to adverse outcomes. However, the immunosuppressive mechanism of PMN-MDSCs remains elusive.… read more here.
Keywords: pmn mdscs; ovarian cancer; cancer; ankrd22 ... See more keywords
Decreased Polymorphonuclear Myeloid-Derived Suppressor Cells and ROS Production Correlated Closely with Bronchopulmonary Dysplasia in Preterm Infants
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9010354
Abstract: Background Bronchopulmonary dysplasia (BPD) is one of the most serious complications in premature infants. Myeloid-derived suppressor cells (MDSCs) have been indicated to promote immune tolerance and induce anti-inflammatory responses during the neonatal stage. However, the… read more here.
Keywords: myeloid derived; preterm infants; pmn mdscs; group ... See more keywords
Abstract 323: CHI3L1 secreting PMN-MDSCs promote IFN-γ signaling in triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-323
Abstract: BACKGROUND: Triple-negative breast cancer (TNBC) is highly malignant and has a poor prognosis because it lacks hormone therapy options. Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), a major component in tumor microenvironment are known to help the… read more here.
Keywords: pmn mdscs; breast cancer; tnbc; chi3l1 ... See more keywords
Abstract A72: IFNAR1 signaling regulates PMN-MDSCs immune suppressive activity in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm18-a72
Abstract: Polymorphnuclear myeloid-derived suppressor cells (PMN-MDSCs) are a subset of MDSCs that are expanded and accumulated in several cancers. The main role of PMN-MDSCs in cancer is the suppression of antitumor immune responses, which leads to… read more here.
Keywords: immune suppressive; pmn mdscs; suppressive activity; cancer ... See more keywords
Frequency and Functional Analysis of Myeloid-Derived Suppressor Cells (MDSCs) in the Peripheral Blood and Bone Marrow of Patients with Chronic Idiopathic Neutropenia (CIN)
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-136500
Abstract: Myeloid-derived suppressor cells (MDSCs) are myeloid cells with immunoregulatory properties characterized mainly by suppression of T-cell responses (Bizymi et al, HemaSphere 2019). They are divided in HLA-DRlow/-/CD11b+/CD33+/CD15+ polymorphonuclear (PMN-MDSCs) and HLA-DRlow/-/CD11b+/CD33+/CD14+ monocytic (M-MDSCs) subsets and… read more here.
Keywords: cin patients; cin; pmn mdscs; mdscs ... See more keywords
Interferon Regulatory Factor 4 Regulates the Development of Polymorphonuclear Myeloid-Derived Suppressor Cells Through the Transcription of c-Myc in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.627072
Abstract: The accumulation of myeloid-derived suppressor cells (MDSCs) is one of the major obstacles to achieve an appropriate anti-tumor immune response and successful tumor immunotherapy. MDSCs in tumor-bearing hosts are primarily polymorphonuclear (PMN-MDSCs). However, the mechanisms… read more here.
Keywords: mdscs; pmn mdscs; cancer; development ... See more keywords
NK Cells and PMN-MDSCs in the Graft From G-CSF Mobilized Haploidentical Donors Display Distinct Gene Expression Profiles From Those of the Non-Mobilized Counterpart
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.657329
Abstract: A recent approach of hematopoietic stem cell (HSC) transplantation from haploidentical donors “mobilized” with G-CSF is based on the selective depletion of αβ T and B lymphocytes from the graft. Through this approach, the patient… read more here.
Keywords: cells pmn; graft; gene expression; mdscs ... See more keywords