Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200306
Abstract: Plasmepsin X (PMX) is an aspartyl protease that processes proteins essential for Plasmodium parasites to invade and egress from host erythrocytes during the symptomatic asexual stage of malaria. PMX substrates possess a conserved cleavage region… read more here.
Keywords: substrate peptidomimetic; falciparum plasmepsin; pmx; peptidomimetic inhibitors ... See more keywords
pmx Webserver: A User Friendly Interface for Alchemistry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.6b00498
Abstract: With the increase of available computational power and improvements in simulation algorithms, alchemical molecular dynamics based free energy calculations have developed into routine usage. To further facilitate the usability of alchemical methods for amino acid… read more here.
Keywords: protein; amino acid; pmx webserver; webserver user ... See more keywords
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01336
Abstract: Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking transmission to mosquitoes, making it a potential multistage drug target.… read more here.
Keywords: safety; pmx; potent; plasmepsin ... See more keywords
Improving Anti-Icing and De-Icing Performances via Thermal-Regulation with Macroporous Xerogel.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c08770
Abstract: The accumulation of ice in winter has brought many problems in industrial production and everyday life, and how to prevent icing or remove ice rapidly has aroused great attention from researchers in recent years. In… read more here.
Keywords: ice; macroporous xerogel; anti icing; pmx ... See more keywords
SAT0475 Anti-mda5 (+) clinically amyopathic dermatomyositis-associated rapidly progressive interstitial lung disease: role of hemoperfusion with polymyxin
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.2594
Abstract: Background Patients with clinically amyopathyc dermatomyositis (CADM) with MDA5 positive autoantibodies may develop a severe pulmonary syndrome with rapidly progressive interstitial lung disease (RP-ILD) with a bad prognosis and high mortality. Objectives To analyse the… read more here.
Keywords: mda5; anti mda5; rapidly progressive; group ... See more keywords
Extended Sessions of Polymyxin-B Immobilized Fiber Column Hemoperfusion Ameliorate Renal Outcome and Mortality in Septic Shock with Acute Kidney Injury
Sign Up to like & getrecommendations! Published in 2018 at "Blood Purification"
DOI: 10.1159/000488639
Abstract: Background/Aims: Polymyxin-B (PMX) treatment has been reported to decrease mortality in patients with septic shock and acute kidney injury (AKI). In this study, we aimed to evaluate whether extended sessions of PMX (Ext-PMX) immobilized fiber… read more here.
Keywords: septic shock; mortality; shock acute; acute kidney ... See more keywords
Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Intensive Care"
DOI: 10.1186/s13613-020-00699-z
Abstract: Background Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sepsis and septic shock, and a rat sepsis model… read more here.
Keywords: microcirculation patients; septic shock; patients septic; pmx ... See more keywords