Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels
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DOI: 10.3389/fphar.2020.633679
Abstract: Despite potently inhibiting the nociceptive voltage-gated sodium (Nav) channel, Nav1.7, ยต-theraphotoxin Pn3a is antinociceptive only upon co-administration with sub-therapeutic opioid agonists, or by itself at doses >3,000-fold greater than its Nav1.7 IC 50 by a… read more here.
Keywords: pn3a; high voltage; inhibition; voltage activated ... See more keywords