Targeting a KRAS i‐motif forming sequence by unmodified and gamma‐modified peptide nucleic acid oligomers
Sign Up to like & getrecommendations! Published in 2022 at "Biopolymers"
DOI: 10.1002/bip.23529
Abstract: Growing interest in i‐motif DNA as a transcriptional regulatory element motivates development of synthetic molecules capable of targeting these structures. In this study, we designed unmodified peptide nucleic acid (PNA) and gamma‐modified PNA (γPNA) oligomers… read more here.
Keywords: spectroscopy; motif forming; pna pna; sequence ... See more keywords
Native Chemical Ligation Directed by Photocleavable Peptide Nucleic Acid (PNA) Templates
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700487
Abstract: A novel peptide–peptide ligation strategy is introduced that has the potential to provide peptide libraries of linearly or branched coupled fragments and will be suited to introduce simultaneous protein modifications at different ligation sites. Ligation… read more here.
Keywords: pna; peptide nucleic; ligation; nucleic acid ... See more keywords
Efficient Gene Therapy of Pancreatic Cancer via a Peptide Nucleic Acid (PNA)-Loaded Layered Double Hydroxides (LDH) Nanoplatform.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.201907233
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignant tumors with extremely poor prognosis due to the later stage diagnosis when surgical resection is no longer applicable. Alternatively, the traditional gene therapy which drives… read more here.
Keywords: pna; gene therapy; pancreatic cancer; cancer ... See more keywords
Facile Preparation of PNA-Peptide Conjugates with a Polar Maleimide-Thioether Linkage.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0243-0_6
Abstract: Conjugation of a delivery peptide containing a thiol functionality (e.g., a cysteine residue) with a PNA oligomer displaying a single unprotected aliphatic primary amine (e.g., the N-terminus or a C-terminal lysine residue) can be achieved… read more here.
Keywords: pna peptide; pna; peptide conjugates; preparation pna ... See more keywords
Novel peptide (RATH) mediated delivery of peptide nucleic acids for antiviral interventions.
Sign Up to like & getrecommendations! Published in 2021 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-021-11502-9
Abstract: The peptide nucleic acid (PNA) is a chimeric molecule with the nucleobases connected by peptide bonds. This chimeric nature gives the PNA certain therapeutic advantages over natural antisense nucleic acid molecules. The PNA probes are… read more here.
Keywords: delivery pna; pna; peptide nucleic; delivery ... See more keywords
Parallel comparison of the 1982/83, 1997/98 and 2015/16 super El Niños and their effects on the extratropical stratosphere
Sign Up to like & getrecommendations! Published in 2017 at "Advances in Atmospheric Sciences"
DOI: 10.1007/s00376-017-6260-x
Abstract: This study uses multiple sea surface temperature (SST) datasets to perform a parallel comparison of three super El Niños and their effects on the stratosphere. The results show that, different from ordinary El Niños, warm… read more here.
Keywords: winter; 1982 1997; pna; super effects ... See more keywords
The influence of ENSO, PDO and PNA on secular rainfall variations in Hawai‘i
Sign Up to like & getrecommendations! Published in 2017 at "Climate Dynamics"
DOI: 10.1007/s00382-017-4003-4
Abstract: Over the last century, significant declines in rainfall across the state of Hawai‘i have been observed, and it is unknown whether these declines are due to natural variations in climate, or manifestations of human-induced climate… read more here.
Keywords: pdo; observed rainfall; pna; influence ... See more keywords
Walking through the wonder years of artificial DNA: peptide nucleic acid.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05819-3
Abstract: Peptide Nucleic Acid (PNA) serves as an artificial functional analog of DNA. Being immune to enzymatic degradation and possessing strong affinity towards DNA and RNA, it is an ideal candidate for many medical and biotechnological… read more here.
Keywords: walking wonder; pna; dna; peptide nucleic ... See more keywords
Structural characteristics of cyclopentane-modified peptide nucleic acids from molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2017 at "Structural Chemistry"
DOI: 10.1007/s11224-017-0970-7
Abstract: A PNA molecule is a DNA strand where the sugar-phosphate backbone has been replaced by a structurally homomorphous pseudopeptide chain consisting of N (2-amino-ethyl)-glycine units. PNA binds strongly to both DNA and RNA. However, an… read more here.
Keywords: nucleic acids; dna; peptide nucleic; pna ... See more keywords
Recent Advances in Peptide Nucleic Acids for Rapid Detection of Foodborne Pathogens
Sign Up to like & getrecommendations! Published in 2020 at "Food Analytical Methods"
DOI: 10.1007/s12161-020-01811-6
Abstract: Peptide nucleic acids (PNAs) are DNA/RNA analogs in which sugar-phosphate backbone is replaced by N -2-aminoethylglycine repeating units. Since PNA contains a neutral skeleton, there is no electrostatic repulsion, resulting in significant stability of its… read more here.
Keywords: rapid detection; nucleic acids; pna; peptide nucleic ... See more keywords
PNA-functionalized magnetic microbeads as substrates for enzyme-labelled voltammetric genoassay for DNA sensing applied to identification of GMO in food.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2021.338297
Abstract: A novel enzyme-labelled voltammetric magnetogenoassay for DNA sensing based on the use of carboxyl-surface coated magnetic microbeads functionalized with PNA probes and subsequent read-out on screen-printed electrode (SPE) substrates was developed. The assay was validated… read more here.
Keywords: dna; pna; labelled voltammetric; magnetic microbeads ... See more keywords