PNA Conjugates of Quinone Methide Precursors Alkylate RNA after Activation with Light.
Sign Up to like & getrecommendations! Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00796
Abstract: Quinone methide precursors 2 and 3 were protected with a photoreactive 2-nitrobenzyl group and conjugated to peptide nucleic acids (PNA) using a Huisgen click reaction. After brief irradiation at 365 nm, crosslinking with com-plementary RNA… read more here.
Keywords: quinone methide; alkylate rna; methide precursors; precursors alkylate ... See more keywords
Automated Flow Synthesis of Peptide–PNA Conjugates
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.1c01019
Abstract: Antisense peptide nucleic acids (PNAs) have yet to translate to the clinic because of poor cellular uptake, limited solubility, and rapid elimination. Cell-penetrating peptides (CPPs) covalently attached to PNAs may facilitate clinical development by improving… read more here.
Keywords: peptide; pna conjugates; automated flow; peptide pna ... See more keywords