The pncA gene mutations of Mycobacterium tuberculosis in multidrug-resistant tuberculosis.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2278
Abstract: The pncA gene encodes Pyrazinamidase enzyme which converts drug pyrazinamide to active form Pyrazinoic acid but mutations in this gene can prevent enzyme activity which leads to pyrazinamide resistance. The cross-sectional study was carried out… read more here.
Keywords: pnca gene; tuberculosis; multidrug resistant; gene ... See more keywords
Characterization of novel Mycobacterium tuberculosis pncA gene mutations in clinical isolates from the Ukraine.
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2018.10.018
Abstract: Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis cases in the Ukraine are increasing. Pyrazinamide (PZA) is critically important for first- and second-line tuberculosis (TB) treatment regimes. However, PZA drug susceptibility testing is time consuming… read more here.
Keywords: mycobacterium tuberculosis; gene; pnca gene; clinical isolates ... See more keywords
Evolutionary Genetic Analysis of the Pyrazinamidase Gene in Seven Global Populations of Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2025 at "International journal of mycobacteriology"
DOI: 10.4103/ijmy.ijmy_30_25
Abstract: BACKGROUND This study aims to identify the signatures of natural selection in the pyrazinamidase (pncA) gene to see if genetic adaptations by Darwinian natural selection have shaped genetic composition of Mycobacterium tuberculosis (Mtb). METHODS The… read more here.
Keywords: gene; mycobacterium tuberculosis; natural selection; pnca gene ... See more keywords