Single‐Cell RNA‐Seq and Machine Learning Reveal Key Feature Genes of Astrocyte in Perioperative Neurocognitive Disorders
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.70085
Abstract: Perioperative neurocognitive disorder (PND) is common in older patients after anesthesia and surgery, significantly increasing morbidity and mortality. However, the role of astrocytes in its pathogenesis remains limitedly understood. Here, we analyzed 9976 and 9484… read more here.
Keywords: single cell; feature genes; machine learning; perioperative neurocognitive ... See more keywords
Are midwives trained to recognise perinatal depression symptoms? Results of MAMA (MAternal Mood Assessment) cross-sectional survey in Italy
Sign Up to like & getrecommendations! Published in 2024 at "Archives of Women's Mental Health"
DOI: 10.1007/s00737-024-01439-z
Abstract: To assess the knowledge, clinical experience, and attitudes of Italian midwives toward perinatal depression (PND) and to explore how these factors impact the quality of care. We conducted a cross-sectional online survey among 152 midwives… read more here.
Keywords: survey; midwives trained; cross sectional; perinatal depression ... See more keywords
Severity of preterm birth and perinatal depressive symptoms in mothers and fathers: trajectories over the first postpartum year.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2021.10.080
Abstract: BACKGROUND Preterm birth has been recognized as a risk factor for perinatal depression (PND), with consequences for parenting and child development; however, the impact of severity of prematurity on parental PND course has not been… read more here.
Keywords: pnd; preterm birth; birth; birth weight ... See more keywords
Direct and indirect determinants of prenatal depression among Arab-Bedouin women in Israel: The role of stressful life events and social support.
Sign Up to like & getrecommendations! Published in 2021 at "Midwifery"
DOI: 10.1016/j.midw.2021.102937
Abstract: OBJECTIVE Prenatal depression (PND) negatively affects the health and well-being of both mother and child. The aim of this study was to identify the direct and indirect determinants of prenatal depression symptoms (PNDS) among Arab-Bedouin… read more here.
Keywords: depression; bedouin women; direct indirect; pnd ... See more keywords
Immunomodulatory effect of Celecoxib on HMGB1/TLR4 pathway in a recurrent seizures model in immature rats
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2018.05.007
Abstract: ABSTRACT Epileptic seizures constitute an important problem in pediatric neurology during the developmental period. The frequency and nosological significance of seizures, as well as their association with epileptogenesis, may be related to underlying mechanisms such… read more here.
Keywords: hmgb1; hmgb1 tlr4; treatment; tlr4 pathway ... See more keywords
Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00744
Abstract: Perioperative neurocognitive disorder (PND) is a common adverse event after surgical trauma in elderly patients. The pathogenesis of PND is still unclear. Adiponectin (APN) is a plasma protein secreted by adipose tissue. We have reported… read more here.
Keywords: cognitive deficits; neuroinflammation oxidative; apn; tlr4 ... See more keywords
Offering a choice between NIPT and invasive PND in prenatal genetic counseling: the impact of clinician characteristics on patients’ test uptake
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-018-0287-z
Abstract: Testing options for pregnant women at increased risk of common aneuploidies are non-invasive prenatal testing (NIPT) and invasive prenatal diagnosis (PND). Clinicians are challenged to comprehensively discuss the complex information in a patient-centered and non-directive… read more here.
Keywords: information; centeredness; nipt invasive; invasive pnd ... See more keywords
Implementing a Perinatal Depression Screening in Clinical Routine: Exploring the Patientʼs Perspective
Sign Up to like & getrecommendations! Published in 2022 at "Geburtshilfe und Frauenheilkunde"
DOI: 10.1055/a-1844-9246
Abstract: Abstract Introduction Perinatal depression (PND) is a frequently observed mental disorder, showing a prevalence of up to 20% and resulting in unfavorable maternal and neonatal outcomes. Targeted screening for PND offers the potential to identify… read more here.
Keywords: pnd; depression; perspective; care ... See more keywords
Identification of measures predictive of age of puberty onset in gilts
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DOI: 10.1093/tas/txz173
Abstract: Abstract A potential indicator of female lifetime productivity in swine is age of puberty, when a gilt achieves her first behavioral estrus. Follicular activity, as determined by tertiary follicle development, in prepubertal gilts begins during… read more here.
Keywords: age; follicular activity; pnd; puberty ... See more keywords
Intergenerational postoperative neurocognitive disorder in a rat model: Initiating mechanisms and pharmacological prevention.
Sign Up to like & getrecommendations! Published in 2025 at "Anesthesiology"
DOI: 10.1097/aln.0000000000005578
Abstract: BACKGROUND Vulnerability to perioperative neurocognitive disorder (PND) and the mechanisms initiating PND, which may serve as targets for prevention, are incompletely understood. We hypothesized that sevoflurane can induce persistent upregulation of the hypothalamic-pituitary-adrenal (HPA) axis,… read more here.
Keywords: sevoflurane; f0m; neurocognitive disorder; f0m f0m ... See more keywords
Identification of perioperative neurocognitive dysfunction biomarkers in cerebrospinal fluid with quantitative proteomic approach in patients undergoing transurethral resection of prostate with combined spinal and epidural analgesia
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030448
Abstract: Background: This study aimed to identify predictive biomarkers of perioperative neurocognitive dysfunction (PND) in cerebrospinal fluid of elderly male patients undergoing elective transurethral resection of prostate, using an isobaric tags for relative and absolute quantitative-based… read more here.
Keywords: cerebrospinal fluid; pnd; proteomic approach; perioperative neurocognitive ... See more keywords