PDZ‐binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23519
Abstract: The therapeutic effects of existing drug regimens against pancreatic neuroendocrine neoplasms (pNENs) remain limited, and identifying ideal therapeutic targets is warranted. PDZ binding kinase (PBK) may play an oncogenic role in most solid tumors. However,… read more here.
Keywords: akt mtor; pancreatic neuroendocrine; mtor pathway; pnen ... See more keywords
Neuropilin-1 (NRP-1) upregulated by IL-6/STAT3 signaling contributes to invasion in pancreatic neuroendocrine neoplasms.
Sign Up to like & getrecommendations! Published in 2018 at "Human pathology"
DOI: 10.1016/j.humpath.2018.06.030
Abstract: Although the upregulation of Neuropilin-1 (NRP-1) is associated with many solid tumors, its role in pancreatic neuroendocrine neoplasms (pNEN) has not been well elucidated. The aim of this study was to investigate the role of… read more here.
Keywords: pancreatic neuroendocrine; neuropilin nrp; expression; pnen ... See more keywords
The link between menin and pleiotrophin in the tumor biology of pancreatic neuroendocrine neoplasms.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer science"
DOI: 10.1111/cas.15301
Abstract: MEN1, which encodes menin protein, is the most frequently mutated gene in pancreatic neuroendocrine neoplasms (pNEN). Pleiotrophin (PTN) was reported being a downstream factor of menin and to promote metastasis in different tumor entities. In… read more here.
Keywords: ptn; menin; pancreatic neuroendocrine; metastasis ... See more keywords
Sporadic pancreatic neuroendocrine neoplasms: A retrospective clinicopathological and outcome analysis from a Latvian study group
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2023.1131333
Abstract: Background Although pancreatic neuroendocrine neoplasms (PNEN) are rare, there has been a constant increase in incidence. Furthermore, PNEN present unique clinical behaviors and long-term survival can be expected even in the presence of metastases as… read more here.
Keywords: pnen; neuroendocrine neoplasms; analysis; pancreatic neuroendocrine ... See more keywords
The Expression of Autophagy-Associated Genes Represents a Valid Footprint for Aggressive Pancreatic Neuroendocrine Neoplasms
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043636
Abstract: Pancreatic neuroendocrine neoplasms (pNEN) are rare and heterogeneous tumors. Previous investigations have shown that autophagy can be a target for cancer therapy. This study aimed to determine the association between the expression of autophagy-associated gene… read more here.
Keywords: expression autophagic; pnen; expression; neuroendocrine neoplasms ... See more keywords