Ewing sarcoma/primitive neuro-ectodermal tumor of the urogenital system in children: a retrospective observational case series.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pediatric urology"
DOI: 10.1016/j.jpurol.2019.06.022
Abstract: INTRODUCTION Pediatric Ewing sarcoma (ES)/primitive neuro-ectodermal tumor (PNET) occurring in the genitourinary system has been rarely reported. And the result of long-term follow-up is still a matter of debate. OBJECTIVE The aim of the study… read more here.
Keywords: system; neuro ectodermal; primitive neuro; pnet ... See more keywords
Prognostic significance of preoperative gamma-glutamyltransferase to lymphocyte ratio index in nonfunctional pancreatic neuroendocrine tumors after curative resection
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13847-6
Abstract: Various inflammation-based prognostic scores have been associated with reduced survival in patients with nonfunctional pancreatic neuroendocrine tumor (NF-PNET). However, few studies have illuminated the relationship between the preoperative gamma-glutamyltransferase (GGT) to lymphocyte ratio index (GLRI)… read more here.
Keywords: pancreatic neuroendocrine; nonfunctional pancreatic; glri; curative resection ... See more keywords
Values of debulking surgery for unresectable well-differentiated metastatic pancreatic neuroendocrine tumors: a comparative study
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology Report"
DOI: 10.1093/gastro/goad010
Abstract: Abstract Background and objective The value of debulking surgery for unresectable well-differentiated metastatic pancreatic neuroendocrine tumor (m-PNET) remains poorly defined. This study aimed to evaluate the outcomes of m-PNET following debulking surgery in our institute.… read more here.
Keywords: surgery; pnet; resection; debulking surgery ... See more keywords
c‐Myc promotes lymphatic metastasis of pancreatic neuroendocrine tumor through VEGFC upregulation
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14717
Abstract: Pancreatic neuroendocrine tumor (pNET) is a pancreatic neoplasm with neuroendocrine differentiation. pNET in early stage can be treated with surgical resection with long‐term survival, whereas the prognosis of pNET with locoregional or distant metastasis is… read more here.
Keywords: tumor; node metastasis; metastasis; lymph node ... See more keywords
Pancreatic Neuroendocrine Tumors and EMT Behavior Are Driven by the CSC Marker DCLK1
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-16-0285
Abstract: Doublecortin-like kinase 1 (DCLK1), a marker for intestinal and pancreatic cancer stem cells, is highly expressed in neuroblastomas. This study was conducted to assess DCLK1 expression levels in pancreatic neuroendocrine tumor (PNET) tissues and to… read more here.
Keywords: pancreatic neuroendocrine; cancer; marker dclk1; marker ... See more keywords
Metastatic pancreatic neuroendocrine tumors feature elevated T cell infiltration
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.160130
Abstract: Pancreatic neuroendocrine tumors (PNETs) are malignancies arising from the islets of Langerhans. Therapeutic options are limited for the over 50% of patients who present with metastatic disease. We aimed to identify mechanisms to remodel the… read more here.
Keywords: cell; metastatic pnets; pnet; neuroendocrine tumors ... See more keywords
RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Investigation"
DOI: 10.1172/jci123049
Abstract: Hyperactivated AKT/mTOR signaling is a hallmark of pancreatic neuroendocrine tumors (PNETs). Drugs targeting this pathway are used clinically, but tumor resistance invariably develops. A better understanding of factors regulating AKT/mTOR signaling and PNET pathogenesis is… read more here.
Keywords: phosphorylation; pnet; akt; rabl6a ... See more keywords
MON-332 Metastatic Pancreatic Neuroendocrine Tumor: A Very Rare Cause of Ectopic ACTH Production (ACTHoma)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-mon-332
Abstract: Abstract Introduction Ectopic ACTH syndrome (EAS)is responsible for 10% of Cushing’s syndrome. Multiple tumors, most commonly small cell carcinoma of lung are associated with EAS. Pancreatic neuroendocrine tumors (pNETs) are usually associated with secretion of… read more here.
Keywords: ectopic acth; pnet; production; tumor ... See more keywords
PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11121902
Abstract: Pancreatic neuroendocrine tumors (PNET) remain an unmet clinical need. In this study, we show that targeting both nicotinamide phosphoribosyltransferase (NAMPT) and p21-activated kinase 4 (PAK4) could become a synthetic lethal strategy for PNET. The expression… read more here.
Keywords: pak4 nampt; pancreatic neuroendocrine; neuroendocrine tumors; nampt dual ... See more keywords
Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13205117
Abstract: Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers whose causation is only partly understood. An increasing number of studies have uncovered molecular changes associated with pNETs, helping to identify common disease mechanisms. This… read more here.
Keywords: research; pancreatic neuroendocrine; therapeutic targets; disease ... See more keywords
Pediatric Orbital Primitive Neuroectodermal Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pediatric ophthalmology and strabismus"
DOI: 10.3928/01913913-20170703-03
Abstract: PURPOSE To present the clinical, radiological, histopathological, immunohistochemical features and the follow-up of orbital primitive neuroectodermal tumors (PNETs) in pediatric patients along with a review of the literature. METHODS A retrospective analysis of all diagnosed… read more here.
Keywords: orbital primitive; pnet; neuroectodermal tumors; primitive neuroectodermal ... See more keywords