Evaluation of pneumococcal meningitis clusters in Burkina Faso and implications for potential reactive vaccination
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DOI: 10.1016/j.vaccine.2020.06.002
Abstract: Highlights • From 2011 to 2017, Burkina Faso had 20 pneumococcal meningitis clusters of ≥ 5 cases per district/week.• Clusters had a maximum weekly incidence of 7 cases and a maximum duration of 4 weeks.•… read more here.
Keywords: pneumococcal meningitis; burkina faso; reactive vaccination; meningitis clusters ... See more keywords
Neutrophil extracellular traps in the central nervous system hinder bacterial clearance during pneumococcal meningitis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09040-0
Abstract: Neutrophils are crucial mediators of host defense that are recruited to the central nervous system (CNS) in large numbers during acute bacterial meningitis caused by Streptococcus pneumoniae. Neutrophils release neutrophil extracellular traps (NETs) during infections… read more here.
Keywords: meningitis; neutrophil extracellular; bacterial clearance; pneumococcal meningitis ... See more keywords
Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52212-7
Abstract: Toll-like receptor (TLR) 2 and 4 signalling pathways are central to the body’s defence against invading pathogens during pneumococcal meningitis. Whereas several studies support their importance in innate immunity, thereby preventing host mortality, any role… read more here.
Keywords: pneumococcal meningitis; double deficiency; long term; mice ... See more keywords
327. Comparison of Clinical Outcome, Causative Serotypes, and Antimicrobial Susceptibilities Between Pneumococcal Meningitis and Pneumococcal Bacteremic Pneumonia in Adult Patients in the Republic of Korea
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DOI: 10.1093/ofid/ofy210.338
Abstract: Abstract Background Pneumococcal meningitis (PM) is one of invasive pneumococcal disease (IPD) and is considered as a medical emergency with notable morbidity and mortality. This study was designed to characterize differences in clinical characteristics and… read more here.
Keywords: serotypes antimicrobial; pneumococcal bacteremic; adult; susceptibilities pneumococcal ... See more keywords
330. Head and Spine Injuries Increase Risk of Streptococcus pneumoniae Meningitis in Adults
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.341
Abstract: Abstract Background In the United States, Streptococcus pneumoniae is responsible for 50% of bacterial meningitis cases. However, pneumococcal vaccines were not recommended for routine childhood immunization until pneumococcal conjugate vaccine became available in 2000, and… read more here.
Keywords: meningitis; risk; streptococcus pneumoniae; head spine ... See more keywords
Clinical and Bacteriological Analysis of Pediatric Pneumococcal Meningitis after 13-Valent Pneumococcal Conjugate Vaccine Introduction in Japan
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DOI: 10.1128/spectrum.01822-21
Abstract: We analyzed 34 cases of pediatric pneumococcal meningitis that were reported after the 13-valent pneumococcal conjugate vaccine (PCV13) introduction era in Japan. Our study revealed that pneumococcal meningitis in children was mainly caused by non-PCV13… read more here.
Keywords: meningitis; pediatric pneumococcal; pcv13 serotypes; pneumococcal meningitis ... See more keywords
Complement factor H contributes to mortality in humans and mice with bacterial meningitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1675-1
Abstract: BackgroundThe complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement factor H (FH) is a… read more here.
Keywords: meningitis; complement factor; bacterial meningitis; mortality ... See more keywords
Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01966-3
Abstract: Background Pneumococcal meningitis (PM) remains a global public health concern and affects all age groups. If acquired during infancy or childhood, permanent neurofunctional deficits including cognitive impairment, cerebral palsy, and secondary epilepsy are typical sequelae… read more here.
Keywords: csf; blood; serum nfl; pneumococcal meningitis ... See more keywords
Pneumococcal meningitis with normal cerebrospinal biochemistry and no pneumococci at microscopy, mimicking a stroke: a case report
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DOI: 10.1186/s13256-017-1287-2
Abstract: BackgroundBacterial meningitis commonly presents with symptoms such as headache, impaired consciousness, neck stiffness, and fever. In most cases, cerebrospinal fluid analysis will yield white cell counts >100/mm3. Atypical presentations occur, especially in the very young… read more here.
Keywords: biochemistry; microscopy; case; pneumococcal meningitis ... See more keywords
Surveillance of impact of PCV-10 vaccine on pneumococcal meningitis in Mozambique, 2013 – 2015
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DOI: 10.1371/journal.pone.0177746
Abstract: Background Vaccination using the 10-valent conjugate vaccine (PCV-10) was introduced into the Extended Program on Immunization in Mozambique in March 2013, however its impact on pediatric pneumococcal meningitis is unknown. In this study, we assessed… read more here.
Keywords: meningitis; 2013 2015; vaccine; impact ... See more keywords
Efficacy assessment of a novel endolysin PlyAZ3aT for the treatment of ceftriaxone-resistant pneumococcal meningitis in an infant rat model
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DOI: 10.1371/journal.pone.0266928
Abstract: Background Treatment failure in pneumococcal meningitis due to antibiotic resistance is an increasing clinical challenge and alternatives to antibiotics warrant investigation. Phage-derived endolysins efficiently kill gram-positive bacteria including multi-drug resistant strains, making them attractive therapeutic… read more here.
Keywords: pneumococcal meningitis; treatment; ceftriaxone resistant; plyaz3at ... See more keywords