Novel processes to obtain pneumococcal surface proteins for vaccines
Sign Up to like & getrecommendations! Published in 2025 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-025-13440-2
Abstract: Current pneumococcal vaccines are based on the protection offered by capsular polysaccharides from only a few from > 100 serotypes; therefore, serotype-independent vaccines composed of pneumococcal surface proteins are being developed. Despite the immense number of publications… read more here.
Keywords: process; pneumococcal surface; pneumococcal vaccines; development ... See more keywords
Pneumococcal surface protein A (PspA) prevents killing of Streptococcus pneumoniae by indolicidin
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-73564-9
Abstract: Pneumococcal surface protein A (PspA) is an important virulence factor in Streptococcus pneumoniae that binds to lactoferrin and protects the bacterium from the bactericidal action of lactoferricins—cationic peptides released upon lactoferrin proteolysis. The present study… read more here.
Keywords: indolicidin; pspa; pneumococcal surface; surface protein ... See more keywords
Association Between Pneumococcal Surface Protein A Family and Genetic/Antimicrobial Resistance Traits of Non-Invasive Pneumococcal Isolates from Adults in Northern Japan.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial drug resistance"
DOI: 10.1089/mdr.2018.0267
Abstract: Pneumococcal isolates from adult patients in northern Japan in 2016 were subjected to molecular investigation related to pneumococcal surface protein A (PspA) and drug resistance determinants. Of the 51 isolates, serotype 3/ST180 was the most… read more here.
Keywords: pneumococcal surface; pneumococcal isolates; family; resistance ... See more keywords
Genetic diversity of pneumococcal surface protein A in invasive pneumococcal isolates from Korean children, 1991-2016
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0183968
Abstract: Pneumococcal surface protein A (PspA) is an important virulence factor of pneumococci and has been investigated as a primary component of a capsular serotype-independent pneumococcal vaccine. Thus, we sought to determine the genetic diversity of… read more here.
Keywords: pneumococcal surface; pneumococcal isolates; genetic diversity; pspa ... See more keywords
Pneumococcal Surface Protein A: A Promising Candidate for the Next Generation of Pneumococcal Vaccines.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2021.67.4.32
Abstract: Streptococcus pneumoniae is the bacterium that causes pneumococcal disease which often results in pneumonia, meningitis, otitis media, septicemia and sinusitis. Pneumonia, particularly, is a significant cause of worldwide morbidity and a global health burden as… read more here.
Keywords: surface protein; protein promising; candidate; pneumococcal surface ... See more keywords
Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1059603
Abstract: Introduction Streptococcus pneumoniae (S. pneumoniae) is one of the most widespread pathogens in the world and one of the largest infectious causes of infant mortality. Although current vaccines have various benefits, antibiotic resistance and the… read more here.
Keywords: immunization; pspa; infection; maternal immunization ... See more keywords