Assessment of polymyxin B - doxycycline combination against Pseudomonas aeruginosa in in vitro and in a mouse acute pneumonia model.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106022
Abstract: The increasing prevalence of antibiotic resistance in Pseudomonas aeruginosa has created an urgent need for suitable therapy. Here we systematically explored the pairing of doxycycline with other antipseudomonal antibiotic partners and found a synergistic combination… read more here.
Keywords: combination; acute pneumonia; pneumonia model; polymyxin doxycycline ... See more keywords
In vivo pharmacokinetic/pharmacodynamic evaluation of cefepime/taniborbactam combination against cefepime-non-susceptible Enterobacterales and Pseudomonas aeruginosa in a murine pneumonia model
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac446
Abstract: Abstract Background Cefepime/taniborbactam is a cephalosporin/bicyclic boronate β-lactamase inhibitor combination in clinical development for nosocomial pneumonia due to MDR Gram-negative bacteria. A murine pneumonia model was used to characterize cefepime/taniborbactam in vivo pharmacodynamics against Enterobacterales… read more here.
Keywords: combination; pneumonia model; cefepime; cefepime taniborbactam ... See more keywords
1245. In Vivo Efficacy of WCK 4282 (High Dose Cefepime [FEP]-Tazobactam [TZB]) Against β-Lactamase-Producing (BLP) Gram-Negative Bacteria in a Neutropenic Murine Pneumonia Model
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.1430
Abstract: Carbapenems are often used for Extended-Spectrum β-lactamase (ESBL)- and cephalosporinase (AmpC or CMY)-producing infections. Their increased use resulted in the emergence of carbapenem resistance among Gram-negatives, promoting the need of an effective carbapenem-sparing option. WCK… read more here.
Keywords: fep; wck 4282; pneumonia model; wck ... See more keywords
Knockdown of EPSTI1 alleviates lipopolysaccharide-induced inflammatory injury through regulation of NF-κB signaling in a cellular pneumonia model.
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DOI: 10.15586/aei.v50i3.581
Abstract: BACKGROUND Although early diagnosis, antibiotic therapies, corticosteroid application, and health care services are conventional managements for pneumonia, antibiotic resistance and adverse reactions remain as limitations for pneumonia treatment. OBJECTIVES The study attempted to evaluate the… read more here.
Keywords: inflammatory injury; cell; knockdown epsti1; pneumonia model ... See more keywords