In vitro and in vivo evaluation of DNase I in reinstating antibiotic efficacy against Klebsiella pneumoniae biofilms.
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DOI: 10.1093/femspd/ftad001
Abstract: Klebsiella pneumoniae is an opportunistic pathogen associated with biofilm-based infections, which are intrinsically antibiotic resistant. Extracellular DNA plays a crucial role in biofilm formation and self-defence, with nucleases being proposed as promising agents for biofilm… read more here.
Keywords: vitro vivo; pneumoniae biofilms; dnase; pneumoniae ... See more keywords
Mycoplasma pneumoniae biofilms grown in vitro: traits associated with persistence and cytotoxicity.
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DOI: 10.1099/mic.0.000928
Abstract: The atypical bacterial pathogen Mycoplasma pneumoniae is a leading etiological agent of community-acquired pneumonia in humans; infections are often recalcitrant, recurrent and resistant to antibiotic treatment. These characteristics suggest a mechanism that facilitates long-term colonization… read more here.
Keywords: pneumoniae biofilms; associated persistence; pneumoniae; mycoplasma pneumoniae ... See more keywords