Single-Dose Combination Nanovaccine Induces Both Rapid and Long-Lived Protection Against Pneumonic Plague.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.10.016
Abstract: Yersinia pestis, the causative agent of pneumonic plague, induces a highly lethal infection if left untreated. Currently, there is no FDA-approved vaccine against this pathogen; however, USAMRIID has developed a recombinant fusion protein, F1-V, that… read more here.
Keywords: combination; combination nanovaccine; rapid long; pneumonic plague ... See more keywords
Robust Th1 cellular and humoral responses generated by the Yersinia pestis rF1-V subunit vaccine formulated to contain an agonist of the CD137 pathway do not translate into increased protection against pneumonic plague.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.07.103
Abstract: Yersinia pestis is the causative agent of plague and is a re-emerging pathogen that also has the potential as a biological weapon, necessitating the development of a preventive vaccine. Despite intense efforts for the last… read more here.
Keywords: protection; plague; th1 cellular; pneumonic plague ... See more keywords
Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abg1787
Abstract: Gepotidacin is a first-in-class triazaacenaphthylene antibacterial agent that selectively inhibits bacterial DNA gyrase and topoisomerase IV through a unique binding mode and has the potential to treat a number of bacterial diseases. Development of this… read more here.
Keywords: pestis; pneumonic plague; plague; model pneumonic ... See more keywords
Combinatorial Viral Vector-Based and Live Attenuated Vaccines without an Adjuvant to Generate Broader Immune Responses to Effectively Combat Pneumonic Plague
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DOI: 10.1128/mbio.03223-21
Abstract: Yersinia pestis, the causative agent of plague, is a Tier-1 select agent and a reemerging human pathogen. A 2017 outbreak in Madagascar with >75% of cases being pneumonic and 8.6% causalities emphasized the importance of… read more here.
Keywords: pneumonic plague; vector; plague; ad5 yfv ... See more keywords
Notes from the Field: Diagnosis and Investigation of Pneumonic Plague During a Respiratory Disease Pandemic - Wyoming, 2021.
Sign Up to like & getrecommendations! Published in 2022 at "MMWR. Morbidity and mortality weekly report"
DOI: 10.15585/mmwr.mm7124a5
Abstract: In September 2021, the Wyoming Department of Health (WDH) was notified of a suspected case of pneumonic plague in an adult who was admitted to a Wyoming hospital after 48 hours of worsening cough, dyspnea,… read more here.
Keywords: pneumonic plague; field diagnosis; notes field; respiratory ... See more keywords
Increasing Virulence in Leprosy Indicated by Global Mycobacterium spp.
Sign Up to like & getrecommendations! Published in 2018 at "Emerging Infectious Diseases"
DOI: 10.3201/eid2401.171785
Abstract: To the Editor: In an investigation of a pneumonic plague outbreak in Madagascar, Ramasindrazana et al. reported isolation of Yersinia pestis from 2 patients and seroconversion in 2 additional patients; these data indicated 4 (28.7%)… read more here.
Keywords: plague; pestis; pneumonic plague; increasing virulence ... See more keywords
Pneumonic Plague in a Dog and Widespread Potential Human Exposure in a Veterinary Hospital, United States
Sign Up to like & getrecommendations! Published in 2019 at "Emerging Infectious Diseases"
DOI: 10.3201/eid2504.181195
Abstract: In December 2017, a dog that had pneumonic plague was brought to a veterinary teaching hospital in northern Colorado, USA. Several factors, including signalment, season, imaging, and laboratory findings, contributed to delayed diagnosis and resulted… read more here.
Keywords: plague dog; exposure; hospital; pneumonic plague ... See more keywords
Spray-Dried Inhalable Powder Formulations of Gentamicin Designed for Pneumonic Plague Therapy in a Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14122646
Abstract: Infection with Yersinia pestis (Y. pestis) may cause pneumonic plague, which is inevitably fatal without treatment. Gentamicin (GM), an aminoglycoside antibiotic, is a drug commonly used in the treatment of plague. However, it requires repeated… read more here.
Keywords: pneumonic plague; spray dried; plague; powder ... See more keywords
Predictors of Survival after Vaccination in a Pneumonic Plague Model
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10020145
Abstract: Background: The need for an updated plague vaccine is highlighted by outbreaks in endemic regions together with the pandemic potential of this disease. There is no easily available, approved vaccine. Methods: Here we have used… read more here.
Keywords: pneumonic plague; vaccination; model; vaccine ... See more keywords