Incidence of pneumonitis following the use of different anaplastic lymphoma kinase tyrosine kinase inhibitor regimens: An updated systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5913
Abstract: OBJECTIVES Anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK TKIs) have shown remarkable clinical activity in patients with non-small-cell lung cancer (NSCLC). However, pneumonitis is a serious side effect of ALK TKIs in NSCLC patients. In… read more here.
Keywords: incidence; kinase; grade pneumonitis; analysis ... See more keywords
Pneumonitis after immune checkpoint inhibitor therapies in patients with acute myeloid leukemia: A retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34229
Abstract: BACKGROUND Immune checkpoint inhibitors (ICI), combined with hypomethylating agents, can be used to treat acute myeloid leukemia (AML), but this strategy results in a high rate of pneumonitis. The authors sought to determine risk factors… read more here.
Keywords: myeloid leukemia; acute myeloid; pneumonitis; immune checkpoint ... See more keywords
Differentiation between immune checkpoint inhibitor‐related and radiation pneumonitis in lung cancer by CT radiomics and machine learning
Sign Up to like & getrecommendations! Published in 2022 at "Medical Physics"
DOI: 10.1002/mp.15451
Abstract: Abstract Purpose Consolidation immunotherapy after completion of chemoradiotherapy has become the standard of care for unresectable locally advanced non‐small cell lung cancer and can induce potentially severe and life‐threatening adverse events, including both immune checkpoint… read more here.
Keywords: lung cancer; pneumonitis; checkpoint inhibitor; immune checkpoint ... See more keywords
Association of immune-related pneumonitis with the presence of preexisting interstitial lung disease in patients with non-small lung cancer receiving anti-programmed cell death 1 antibody
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02431-8
Abstract: The safety of anti-programmed cell death 1 (PD-1) antibody for patients with preexisting interstitial lung disease (ILD) remains unknown. The aim of this study was to evaluate the dependence of preexisting ILD on anti-PD-1 antibody-induced… read more here.
Keywords: preexisting ild; anti antibody; antibody; patients preexisting ... See more keywords
CT findings associated with survival in chronic hypersensitivity pneumonitis
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DOI: 10.1007/s00330-017-4936-3
Abstract: AbstractObjectivesTo identify CT findings in chronic hypersensitivity pneumonitis (cHP) associated with survival.Material and methodsTwo thoracic radiologists assessed CT scans for specific imaging findings and patterns in 132 subjects with cHP. Survival analyses were performed.ResultsThe majority… read more here.
Keywords: fibrosis; associated survival; chronic hypersensitivity; hypersensitivity pneumonitis ... See more keywords
Clinical and radiation dose-volume factors related to pneumonitis after treatment with radiation and durvalumab in locally advanced non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Investigational New Drugs"
DOI: 10.1007/s10637-020-00917-2
Abstract: Introduction Durvalumab has been shown to confer a survival benefit after definitive chemoradiotherapy in the patients with locally advanced non-small cell lung cancer, but no studies have attempted to identify risk factors for pneumonitis after… read more here.
Keywords: dose volume; radiation dose; radiation; pneumonitis ... See more keywords
Are there overlapping clinical features between thoracic radiotherapy side effects and covid-19 pneumonia? Radiation pneumonitis outside the radiation ports: Three case reports
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Radiation Oncology"
DOI: 10.1016/j.ctro.2020.09.007
Abstract: Respiratory involvement of Covid-19 infection, presenting as a mild flu-like illness to potentially lethal acute respiratory distress syndrome is the main clinical manifestation in adults. Chest imaging shows a pictorial fashion of images due to… read more here.
Keywords: outside radiation; thoracic radiotherapy; radiation ports; radiation pneumonitis ... See more keywords
ES17.03 Imaging of Pneumonitis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2021.08.752
Abstract: Pneumonitis is one of the major adverse events from systemic anti-cancer therapy and provides clinical challenges in oncology practice. Imaging plays a key role in detection, diagnosis, and monitoring of pneumonitis in cancer patients. This… read more here.
Keywords: inhibitor; radiology; hatabu; nishino ... See more keywords
Pneumonitis in advanced non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitor: Meta-analysis of 153 cohorts with 15,713 patients: Meta-analysis of incidence and risk factors of EGFR-TKI pneumonitis in NSCLC.
Sign Up to like & getrecommendations! Published in 2018 at "Lung cancer"
DOI: 10.1016/j.lungcan.2018.06.032
Abstract: PURPOSE Pneumonitis is a significant toxicity of EGFR tyrosine kinase inhibitors (EGFR-TKI) in non-small-cell lung cancer (NSCLC) patients. We studied the incidence of pneumonitis in clinical trials of EGFR-TKI published in 2003-2017, and performed subgroups… read more here.
Keywords: incidence; grade; lung cancer; pneumonitis ... See more keywords
Radiographic patterns of symptomatic radiation pneumonitis in lung cancer patients: Imaging predictors for clinical severity and outcome.
Sign Up to like & getrecommendations! Published in 2020 at "Lung cancer"
DOI: 10.1016/j.lungcan.2020.03.023
Abstract: OBJECTIVE Investigate the spectrum of radiographic patterns of radiation pneumonitis (RP) in lung cancer patients and identify imaging markers for high-grade RP and RP-related death. METHODS Eighty-two patients with lung cancer treated with conventional chest… read more here.
Keywords: high grade; lung cancer; pneumonitis; grade ... See more keywords
Characterizing immune-mediated adverse events with durvalumab in patients with unresectable stage III NSCLC: A post-hoc analysis of the PACIFIC trial.
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DOI: 10.1016/j.lungcan.2022.02.003
Abstract: INTRODUCTION Immune-mediated adverse events (imAEs), including all-cause immune-mediated pneumonitis, were reported in approximately 25% of patients in the placebo-controlled, phase III PACIFIC trial of durvalumab monotherapy (for up to 12 months) in patients with unresectable, stage… read more here.
Keywords: durvalumab; imaes; pneumonitis; non pneumonitis ... See more keywords