IFNγ receptor down‐regulation facilitates Legionella survival in alveolar macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ma1019-152r
Abstract: Legionella pneumophila is an opportunistic human pathogen and causative agent of the acute pneumonia known as Legionnaire's disease. Upon inhalation, the bacteria replicate in alveolar macrophages (AM), within an intracellular vacuole termed the Legionella‐containing vacuole.… read more here.
Keywords: ifngr1 regulation; pneumophila; regulation; alveolar macrophages ... See more keywords
Legionella pneumophila decreases velocity of Acanthamoeba castellanii.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2017.07.013
Abstract: Acanthamoeba castellanii is a free-living amoeba commonly found in aquatic environment. It feeds on bacteria even if some bacteria resist amoebal digestion. Thus, A. castellanii is described as a Trojan horse able to harbor pathogenic bacteria.… read more here.
Keywords: castellanii; velocity; acanthamoeba castellanii; legionella pneumophila ... See more keywords
Activation of the Legionella pneumophila LegK7 effector kinase by the host MOB1 protein.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.166746
Abstract: Legionella pneumophila infects alveolar macrophages and can cause life-threatening pneumonia in humans. Upon internalization into the host cell, L. pneumophila injects numerous effector proteins into the host cytoplasm as a part of its pathogenesis. LegK7… read more here.
Keywords: host mob1; legk7; kinase; mob1 protein ... See more keywords
NosP modulates cyclic-di-GMP signaling in Legionella pneumophila.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00618
Abstract: Biofilms form when bacteria adhere to a surface and secrete an extracellular polymeric substance. Bacteria embedded within a biofilm benefit from increased resistance to antibiotics, host immune responses, and harsh environmental factors. Nitric oxide (NO)… read more here.
Keywords: nosp modulates; gmp; pneumophila; gmp signaling ... See more keywords
Antibiotic susceptibility of clinical Legionella pneumophila serogroup 1 strains isolated in Germany
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx386
Abstract: Sir, Since the introduction of the first antibiotic agents into the therapy of bacterial diseases, the development of resistance to antibiotics in human bacterial pathogens has been extensively described. For Legionella, an environmental pathogen with… read more here.
Keywords: susceptibility; legionella pneumophila; pneumophila; pneumophila serogroup ... See more keywords
A Supervised Statistical Learning Approach for Accurate Legionella pneumophila Source Attribution during Outbreaks
Sign Up to like & getrecommendations! Published in 2017 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01482-17
Abstract: ABSTRACT Public health agencies are increasingly relying on genomics during Legionnaires' disease investigations. However, the causative bacterium (Legionella pneumophila) has an unusual population structure, with extreme temporal and spatial genome sequence conservation. Furthermore, Legionnaires' disease… read more here.
Keywords: legionnaires disease; source; legionella pneumophila; pneumophila ... See more keywords
Impact of Chlorine and Chloramine on the Detection and Quantification of Legionella pneumophila and Mycobacterium Species
Sign Up to like & getrecommendations! Published in 2019 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01942-19
Abstract: The primary purpose of tap water disinfection is to control the presence of microbes. This study evaluated the role of disinfectant choice on the presence at the tap of L. pneumophila, its Sg1 serogroup, and… read more here.
Keywords: pneumophila; water; chloramine; tclr ... See more keywords
Chlorine and Monochloramine Disinfection of Legionella pneumophila Colonizing Copper and Polyvinyl Chloride Drinking Water Biofilms
Sign Up to like & getrecommendations! Published in 2019 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.02956-18
Abstract: Microbial regrowth within building water systems are promoted by water stagnation, low disinfectant residual, high surface-to-volume ratio, amenable growth temperatures, and colonization of drinking water biofilms. Moreover, biofilms provide protection from environmental stresses, access to… read more here.
Keywords: chlorine; pneumophila; water; water biofilms ... See more keywords
A Two-Component System That Modulates Cyclic di-GMP Metabolism Promotes Legionella pneumophila Differentiation and Viability in Low-Nutrient Conditions
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bacteriology"
DOI: 10.1128/jb.00253-19
Abstract: Although an intracellular pathogen, L. pneumophila has developed mechanisms to ensure long-term survival in low-nutrient aqueous conditions. Eradication of L. pneumophila from contaminated water supplies has proven challenging, as outbreaks have been traced to previously… read more here.
Keywords: system; low nutrient; pneumophila; two component ... See more keywords
Transposon Insertion Sequencing in a Clinical Isolate of Legionella pneumophila Identifies Essential Genes and Determinants of Natural Transformation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bacteriology"
DOI: 10.1128/jb.00548-20
Abstract: Legionella pneumophila is the etiologic agent of a severe form of nosocomial and community-acquired pneumonia in humans. The environmental life traits of L. pneumophila are essential to its ability to accidentally infect humans. ABSTRACT Legionella… read more here.
Keywords: legionella pneumophila; transposon insertion; pneumophila; essential genes ... See more keywords
Evolution of the Arsenal of Legionella pneumophila Effectors To Modulate Protist Hosts
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DOI: 10.1128/mbio.01313-18
Abstract: Within the human host, Legionella pneumophila replicates within alveolar macrophages, leading to pneumonia. However, L. pneumophila is an aquatic generalist pathogen that replicates within a wide variety of protist hosts, including amoebozoa, percolozoa, and ciliophora.… read more here.
Keywords: replicates within; legionella pneumophila; protist hosts; pneumophila ... See more keywords