Evaluation of Clinical Usefulness of Monocyte Gating Using CD14 and CD64 for Detecting PNH Clone By Flow Cytometry
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DOI: 10.1182/blood-2018-99-111468
Abstract: Introduction Flow cytometry is the gold standard in diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) by detecting the absence of glycol-phosphatidyl inositol (GPI)-linked protein expression on red blood cell, granulocyte, and monocyte. The current assays are… read more here.
Keywords: cd14 cd64; pnh clone; clone; monocyte ... See more keywords
Iron Overload in Patients with Paroxysmal Nocturnal Hemoglobinuria
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DOI: 10.1182/blood-2018-99-114654
Abstract: Background: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal bone marrow disorder caused by a somatic mutation in PIGA that leads to a marked deficiency or absence of the complement regulatory proteins CD55 and CD59.… read more here.
Keywords: iron metabolism; pnh; pnh clone; iron overload ... See more keywords
Influence of Paroxysmal Nocturnal Hemoglobinuria Clone Positivity on Outcome of Childhood Acquried Aplastic Anemia: A Multicenter Center Study
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DOI: 10.1182/blood-2018-99-118858
Abstract: Introduction: Paroxysmal nocturnal hemoglobinuria(PNH) in the classical hemolytic form is rare among childhood and children may present with aplastic anemia (AA) phenotype or with an overlapping phenotype of both aplastic and hemolytic components. In the… read more here.
Keywords: clone positivity; pnh clone; aplastic anemia; clone ... See more keywords