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Published in 2017 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2016.04.009
Abstract: A variety of human neurologic diseases are caused by inherited defects in DNA repair. In many cases, these syndromes almost exclusively impact the nervous system, underscoring the critical requirement for genome stability in this tissue.…
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Keywords:
kinase phosphatase;
pnkp;
polynucleotide kinase;
pnkp mutations ... See more keywords
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Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00333-22
Abstract: The 2015–2017 Zika virus (ZIKV) outbreak in Brazil and subsequent international epidemic revealed the strong association between ZIKV infection and congenital malformations, mostly neurodevelopmental defects up to microcephaly. The scale and global expansion of the…
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Keywords:
dna damage;
zika virus;
zikv;
pnkp ... See more keywords
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2
Published in 2022 at "Molecules"
DOI: 10.3390/molecules27249019
Abstract: Sensitive detection methods for T4 polynucleotide kinase/phosphatase (T4 PNKPP) are urgently required to obtain information on malignancy and thereby to provide better guidance in PNKP-related diagnostics and drug screening. Although the CRISPR/Cas12a system shows great…
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Keywords:
system;
guide rna;
detection;
crispr cas12a ... See more keywords