A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation
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DOI: 10.1016/j.molcel.2021.05.032
Abstract: Summary Polynucleotide phosphorylase (PNPase) is an ancient exoribonuclease conserved in the course of evolution and is found in species as diverse as bacteria and humans. Paradoxically, Escherichia coli PNPase can act not only as an… read more here.
Keywords: pnpase; cooperative pnpase; hfq; rna carrier ... See more keywords
Novel biallelic mutations in the PNPT1 gene encoding a mitochondrial‐RNA‐import protein PNPase cause delayed myelination
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DOI: 10.1111/cge.13068
Abstract: Recent studies suggest that impaired transcription or mitochondrial translation of small RNAs can cause abnormal myelination. A polynucleotide phosphorylase (PNPase) encoded by PNPT1 facilitates the import of small RNAs into mitochondria. PNPT1 mutations have been… read more here.
Keywords: pnpase; delayed myelination; pnpt1; myelination ... See more keywords
PNPase knockout results in mtDNA loss and an altered metabolic gene expression program
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DOI: 10.1371/journal.pone.0200925
Abstract: Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implicated in multiple biological processes and human disorders. To reveal role(s) for PNPase in mitochondria, we established PNPase knockout (PKO) systems by first shifting culture conditions to… read more here.
Keywords: pnpase; results mtdna; gene expression; pko ... See more keywords