Thwart your destiny; effect of nonacoholic fatty liver disease genes on steatosis, liver injury and cirrhosis varies by body mass index
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29739
Abstract: Most common human diseases develop because of a combination of endogenous risk combined with exposures. Said another way, these diseases are attributed to genetic risk combined with environmental triggers. Nonalcoholic fatty liver disease (NAFLD) is… read more here.
Keywords: risk; pnpla3 bmi; pnpla3 pnpla3; disease ... See more keywords
Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31238
Abstract: We hypothesized that a genetic risk score (GRS) for fatty liver disease influences the risk of cirrhosis and hepatocellular carcinoma (HCC). Three genetic variants (patatin‐like phospholipase domain–containing protein 3 [PNPLA3] p.I148M; transmembrane 6, superfamily member… read more here.
Keywords: hepatocellular carcinoma; pnpla3; risk cirrhosis; cirrhosis hepatocellular ... See more keywords
Combination of PNPLA3 and TLL1 polymorphism can predict advanced fibrosis in Japanese patients with nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-017-1372-8
Abstract: BackgroundHepatic fibrosis is an independent risk factor for mortality and liver-related events in patients with nonalcoholic fatty liver disease (NAFLD). PNPLA3 rs738409 has been associated with fibrosis in viral and non-viral hepatitis. TLL1 rs17047200 also… read more here.
Keywords: risk; tll1; fibrosis; japanese patients ... See more keywords
PNPLA3 variant and portal/periportal histological pattern in patients with biopsy-proven non-alcoholic fatty liver disease: a possible role for oxidative stress
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15943-z
Abstract: Pathogenesis of non-alcoholic fatty liver disease (NAFLD) is influenced by predisposing genetic variations, dysmetabolism, systemic oxidative stress, and local cellular and molecular cross-talks. Patatin-like phospholipase domain containing 3 (PNPLA3) gene I148M variant is a known… read more here.
Keywords: histological pattern; stress; activation; pnpla3 ... See more keywords
PNPLA3 I148M and response to treatment for hepatic steatosis: A systematic review
Sign Up to like & getrecommendations! Published in 2023 at "Liver International"
DOI: 10.1111/liv.15533
Abstract: It is unclear whether the patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) rs738409 C‐to‐G single nucleotide polymorphism, resulting in the substitution of isoleucine to methionine at position 148 (I148M), impedes regression of hepatic steatosis when treating… read more here.
Keywords: pnpla3 i148m; pnpla3; response treatment; hepatic steatosis ... See more keywords
PNPLA3 variation and kidney disease
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DOI: 10.1111/liv.16010
Abstract: Accumulating epidemiological evidence shows that the patatin‐like phospholipase domain‐containing protein‐3 (PNPLA3) rs738409 G allele, which is the most robust genetic variant associated with greater susceptibility to metabolic dysfunction‐associated steatotic liver disease (MASLD), is significantly associated… read more here.
Keywords: pnpla3; rs738409 allele; risk; pnpla3 rs738409 ... See more keywords
Integrating PNPLA3 into clinical risk prediction
Sign Up to like & getrecommendations! Published in 2024 at "Liver International"
DOI: 10.1111/liv.16103
Abstract: The PNPLA3‐rs738409‐G variant was the first common variant associated with hepatic fat accumulation and progression of metabolic dysfunction‐associated steatotic liver disease (MASLD). Nevertheless, to date, the clinical translation of this discovery has been minimal because… read more here.
Keywords: risk prediction; pnpla3; integrating pnpla3; risk ... See more keywords
Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology Research and Practice"
DOI: 10.1155/2020/4216451
Abstract: A single-nucleotide polymorphism causing a C to G change in the PNPLA3 gene (rs738409) is associated with disease severity and development of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease; the insertion variant rs72613567:TA of… read more here.
Keywords: risk; hcc; hepatitis; hsd17b13 ... See more keywords
PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells
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DOI: 10.1371/journal.pone.0260721
Abstract: Non-alcoholic steatohepatitis (NASH) results, in part, from the interaction of metabolic derangements with predisposing genetic variants, leading to liver-related complications and mortality. The strongest genetic determinant is a highly prevalent missense variant in patatin-like phospholipase… read more here.
Keywords: expression; stellate cells; pnpla3; hepatic stellate ... See more keywords
Association of PNPLA3 SNP With the Development of HBV-related Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "In Vivo"
DOI: 10.21873/invivo.13139
Abstract: Abstract Background/Aim: Concomitant nonalcoholic fatty liver disease (NAFLD)/hepatic steatosis (HS) is suggested to increase the risk of hepatocellular carcinoma (HCC) in hepatitis virus B (HBV)-infected patients. Patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 gene single-nucleotide polymorphism… read more here.
Keywords: hbv; pnpla3; development; hcc ... See more keywords
PNPLA3 Single Nucleotide Polymorphism Prevalence and Association with Liver Disease in a Diverse Cohort of Persons Living with HIV
Sign Up to like & getrecommendations! Published in 2021 at "Biology"
DOI: 10.3390/biology10030242
Abstract: Simple Summary In this pilot study, we determined the prevalence of single nucleotide polymorphisms (SNPs) in the PNPLA3 gene among persons living with HIV (PLWH). Overall, approximately 40% of the population carries at least one… read more here.
Keywords: hiv; single nucleotide; cohort; liver disease ... See more keywords