Synergistic Associations of PNPLA3 I148M Variant, Alcohol Intake, and Obesity With Risk of Cirrhosis, Hepatocellular Carcinoma, and Mortality
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.34221
Abstract: This cohort study assesses the association of behavioral risk factors and genetic variants with risk of liver disease–related morbidity and mortality among middle-aged individuals. read more here.
Keywords: synergistic associations; pnpla3 i148m; mortality; risk ... See more keywords
PNPLA3 I148M and liver fat and fibrosis scores predict liver disease mortality in the United States population.
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.31032
Abstract: BACKGROUND AND AIMS Fatty liver causes premature death worldwide and requires long-term health care. We examined relationships of liver disease markers, including patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148M, with mortality in the U.S. National… read more here.
Keywords: fibrosis; liver disease; mortality; liver fat ... See more keywords
To be, or not to be: the Quest for PNPLA3 p.I148M function.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32096
Abstract: Understanding the mechanisms underpinning the association between rs738409 C>G encoding for the common p.I148M variant of patatin-like phospholipase domain-containing 3 (PNPLA3) with fat accumulation in hepatocytes may hold the key to unravel new treatments for… read more here.
Keywords: quest pnpla3; i148m; liver; i148m function ... See more keywords
PNPLA3 I148M gene variant and chronic kidney disease in type 2 diabetic patients with NAFLD: Clinical and experimental findings
Sign Up to like & getrecommendations! Published in 2020 at "Liver International"
DOI: 10.1111/liv.14419
Abstract: Emerging evidence suggests an association between patatin‐like phospholipase domain‐containing protein‐3 (PNPLA3) rs738409 (I148M protein variant) and risk of chronic kidney disease (CKD), but the mechanisms underpinning this association are poorly understood. read more here.
Keywords: i148m gene; pnpla3 i148m; kidney disease; chronic kidney ... See more keywords
PNPLA3 I148M and response to treatment for hepatic steatosis: A systematic review
Sign Up to like & getrecommendations! Published in 2023 at "Liver International"
DOI: 10.1111/liv.15533
Abstract: It is unclear whether the patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) rs738409 C‐to‐G single nucleotide polymorphism, resulting in the substitution of isoleucine to methionine at position 148 (I148M), impedes regression of hepatic steatosis when treating… read more here.
Keywords: pnpla3 i148m; pnpla3; response treatment; hepatic steatosis ... See more keywords
Impact of PNPLA3 I148M on Drug‐Induced Hepatocellular Liver Injury: A Systematic Review and Meta‐Analysis
Sign Up to like & getrecommendations! Published in 2025 at "Liver International"
DOI: 10.1111/liv.70287
Abstract: The role of the patatin‐like phospholipase domain‐containing protein 3 (PNPLA3)‐I148M variant in drug‐induced liver injury (DILI) remains unclear. This systematic review with meta‐analysis investigated whether carriage of PNPLA3 I148M may contribute to the development of… read more here.
Keywords: meta analysis; drug induced; systematic review; pnpla3 i148m ... See more keywords
Pnpla3 I148M Mutation Causes Cardiovascular and Renal Disease in Mice
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.1673
Abstract: Polymorphism in the patatin-like phospholipid domain-containing protein 3 ( Pnpla3 ) is linked to metabolic dysfunction-associated steatotic liver disease (MASLD). In the US, >30% of MASLD patients have the most common type of Pnpla3 polymorphism… read more here.
Keywords: nsd hsd; mice; physiology; hsd ... See more keywords