Inhibiting the Mitochondrial RNA Degradosome Complex SUV3 and Pnpase Increases dsRNA in the Cytoplasm, Triggers a Viral Mimicry Response and Kills AML Cells and Progenitors
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood-2022-158326
Abstract: Eukaryotic cells have two separate genomes; nuclear chromosomal DNA and circular mitochondrial DNA. Mitochondrial DNA lacks introns, and encodes 2 rRNAs, 22 t-RNAs and 13 of the 90 proteins that constitute the mitochondrial respiratory chain.… read more here.
Keywords: response; pnpt1 supv3l1; aml cells; viral mimicry ... See more keywords