Phoneutria toxin PnTx3-5 inhibits TRPV1 channel with antinociceptive action in an orofacial pain model
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DOI: 10.1016/j.neuropharm.2019.107826
Abstract: Capsaicin, an agonist of TRPV1, evokes intracellular [Ca2+] transients and glutamate release from perfused trigeminal ganglion. The spider toxin PnTx3-5, native or recombinant, and SB-366791 PnTx3-5 is thus more potent than the selective TRPV1 blocker… read more here.
Keywords: trpv1; antinociceptive action; pntx3; toxin ... See more keywords