Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02092-6
Abstract: Alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonists can prevent glutamate-induced excitotoxicity in cultured retinal ganglion cells (RGCs). However, the neuroprotective effects and the mechanism of action of PNU-282987, an α7-nAChR agonist, in a chronic in vivo… read more here.
Keywords: pnu 282987; retinal ganglion; nicotinic acetylcholine; receptor ... See more keywords
Nicotinic α7 receptor‐induced adenosine release from perisynaptic Schwann cells controls acetylcholine spillover from motor endplates
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DOI: 10.1111/jnc.14975
Abstract: Acetylcholine (ACh) spillover from motor endplates occurs after neuronal firing bursts being potentiated by cholinesterase inhibitors (e.g., neostigmine). Nicotinic α7 receptors (α7nAChR) on perisynaptic Schwann cells (PSCs) can control ACh spillover by unknown mechanisms. We… read more here.
Keywords: pnu 282987; microscopy; inhibition; spillover ... See more keywords
The α7 nicotinic acetylcholine receptor agonist PNU-282987 ameliorates sepsis-induced acute kidney injury through CD4+CD25+ regulatory T cells in rats
Sign Up to like & getrecommendations! Published in 2022 at "Bosnian Journal of Basic Medical Sciences"
DOI: 10.17305/bjbms.2022.7111
Abstract: The ameliorative effects of α7 nicotinic acetylcholine receptor (α7nAChR) agonists have been demonstrated in acute kidney injury (AKI) caused by multiple stimulations. However, the ameliorative effect of α7nAChR on sepsis-induced AKI (SAKI) in the cecal… read more here.
Keywords: acute kidney; kidney injury; nicotinic acetylcholine; pnu 282987 ... See more keywords
A Selective α7 Nicotinic Acetylcholine Receptor Agonist, PNU-282987, Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.598165
Abstract: Background The anti-inflammatory effect of an α7nAChR agonist, PNU-282987, has previously been explored in the context of inflammatory disease. However, the effects of PNU-282987 on type 2 innate lymphoid cells (ILC2s)-mediated allergic airway inflammation has… read more here.
Keywords: induced airway; pnu 282987; agonist pnu; airway inflammation ... See more keywords
Involvement of HB-EGF/Ascl1/Lin28a Genes in Dedifferentiation of Adult Mammalian Müller Glia
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.00200
Abstract: Previous studies from this lab have determined that dedifferentiation of Müller glia occurs after eye drop application of an α7 nicotinic acetylcholine receptor (nAChR) agonist, PNU-282987, to the adult rodent eye. PNU-282987 acts on α7… read more here.
Keywords: ascl1 lin28a; ller; pnu 282987; adult ... See more keywords
Protective effects of PNU‑282987 on sepsis‑induced acute lung injury in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular medicine reports"
DOI: 10.3892/mmr.2019.10016
Abstract: The cholinergic anti‑inflammatory pathway is considered an attractive approach for the alleviation of inflammatory diseases. Sepsis is characterized by systemic inflammation and widespread organ injury, especially that in the lung. In the present study, we… read more here.
Keywords: sepsis; lung injury; pnu 282987; sepsis induced ... See more keywords