Total Synthesis of (+)-Pochonin D and (+)-Monocillin II via Chemo- and Regioselective Intramolecular Nitrile Oxide Cycloaddition.
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DOI: 10.1021/acs.orglett.7b03054
Abstract: Asymmetric total syntheses of (+)-pochonin D (1) and (+)-monocillin II (2), Hsp90 inhibitors with potent anticancer activity, have been accomplished where the macrolactone 3 was constructed through a chemo- and regioselective intramolecular nitrile oxide cycloaddition… read more here.
Keywords: regioselective intramolecular; nitrile oxide; pochonin monocillin; chemo regioselective ... See more keywords