Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
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DOI: 10.7554/elife.83602
Abstract: The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at… read more here.
Keywords: pocket opening; blebbistatin; pocket; motor ... See more keywords