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   Articles with "podocalyxin" as a keyword



Podocalyxin molecular characteristics and endometrial expression: high conservation between humans and macaques but divergence in mice

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recommendations! Published in 2022 at "Biology of Reproduction"

DOI: 10.1093/biolre/ioac053

Abstract: Abstract Podocalyxin (PODXL) is a newly identified key negative regulator of human endometrial receptivity, specifically down-regulated in the luminal epithelium at receptivity to permit embryo implantation. Here, we bioinformatically compared the molecular characteristics of PODXL… read more here.

Keywords: podocalyxin; podxl; receptivity; expression ... See more keywords

Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1101/2022.11.04.515043

Abstract: The glycocalyx component and sialomucin Podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Elevated PODXL expression is also associated with metastasis and poor clinical… read more here.

Keywords: glycocalyx component; podocalyxin; podxl; spatial regulation ... See more keywords

Abstract C108: The therapeutic candidate antibody PODO447 recognizes a glycopeptide on podocalyxin-expressing tumor cells that have undergone a partial epithelial-mesenchymal transition

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recommendations! Published in 2025 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.targ-25-c108

Abstract: In tumor cells, protein glycosylation patterns are often dramatically altered compared to normal cells. This leads to the emergence of novel neo-antigens on the tumour cell surface. Podocalyxin is a heavily glycosylated transmembrane sialomucin that… read more here.

Keywords: antibody; podocalyxin; tumor cells; tumor ... See more keywords

Abstract 4911: Characterizing the role of podocalyxin's cytoplasmic tail domain in collective tumor invasion

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recommendations! Published in 2020 at "Cancer Research"

DOI: 10.1158/1538-7445.am2020-4911

Abstract: High expression of the single-pass transmembrane sialomucin, podocalyxin, has been shown by many groups to correlate with poor disease outcome in a number of solid tumor types, including colorectal, ovarian, pancreatic and breast cancers. We… read more here.

Keywords: podocalyxin; invasion; collective tumor; cytoplasmic tail ... See more keywords

Podocalyxin Expressed in Antigen Presenting Cells Promotes Interaction With T Cells and Alters Centrosome Translocation to the Contact Site

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.835527

Abstract: Podocalyxin (PODXL), a cell surface sialomucin expressed in diverse types of normal and malignant cells, mediates cellular adhesion to extracellular matrix and cell-to-cell interaction. A previous study reported the expression of PODXL protein on monocytes… read more here.

Keywords: interaction; podocalyxin; podxl; antigen presenting ... See more keywords