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   Articles with "podocyte" as a keyword



The role of vasodilator‐stimulated phosphoprotein in podocyte functioning

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recommendations! Published in 2019 at "Cell Biology International"

DOI: 10.1002/cbin.11149

Abstract: Vasodilator‐stimulated phosphoprotein (VASP) is a 39‐kDa protein belonging to the Ena/VASP protein family, which is involved in adhesion, migration, cell–cell interaction, and regulation of pathways connected with actin cytoskeleton remodeling. VASP is phosphorylated at Tyr39,… read more here.

Keywords: stimulated phosphoprotein; vasodilator stimulated; podocyte; protein kinase ... See more keywords

The Podocyte Count Detected by an Improved Immunocytochemical Method has Higher Diagnostic Efficiency than Enzyme‐Linked Immunosorbent Assay and Serum Cystatin C to Evaluate the Early Stage Damage of Glomerular

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recommendations! Published in 2017 at "Journal of Clinical Laboratory Analysis"

DOI: 10.1002/jcla.22029

Abstract: In renal diseases, earlier injury to glomerular may lead to the abscission of podocyte. The number of podocyte in urine may reflect the severity of glomerular damage. Podocalyxin (PCX) was considered as a podocyte marker.… read more here.

Keywords: improved immunocytochemical; podocyte; damage; count ... See more keywords

Aberrant localization of β1 integrin in podocyte cytoplasm of primary FSGS with cellular lesion

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recommendations! Published in 2024 at "Virchows Archiv"

DOI: 10.1007/s00428-024-03919-0

Abstract: Podocyte detachment is a major trigger in pathogenesis of focal segmental glomerulosclerosis (FSGS). Detachment via β1 integrin (ITGB1) endocytosis, associated with endothelial cell injury, has been reported in animal models but remains unknown in human… read more here.

Keywords: cel cel; cel; mcns; podocyte ... See more keywords

Slight acceleration in podocyte mRNA loss in preterm-born children aged 3-5 years.

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recommendations! Published in 2025 at "Pediatric nephrology"

DOI: 10.1007/s00467-025-06983-z

Abstract: The global survival rate of preterm infants has been progressively increasing. However, concerns regarding their long-term prognosis persist. This study aimed to investigate podocyte mRNA loss in 3–5-year-old full-term and preterm children to elucidate the… read more here.

Keywords: mrna loss; preterm; podocyte mrna; podocyte ... See more keywords

Knocking down Cabin1 induces glomerular podocyte injury

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recommendations! Published in 2018 at "International Urology and Nephrology"

DOI: 10.1007/s11255-018-1787-z

Abstract: BackgroundPodocyte damage exerts a key role in proteinuria. We have demonstrated that calcineurin-binding protein 1 (Cabin1) upregulated during podocyte injury, yet its function in podocyte is still unclear.MethodsWe established 5/6 nephrectomized rats and angiotensin II… read more here.

Keywords: cabin1; knocking cabin1; podocyte; cabin1 induces ... See more keywords

In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes.

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recommendations! Published in 2019 at "Developmental cell"

DOI: 10.1016/j.devcel.2019.06.001

Abstract: The renal corpuscle of the kidney comprises a glomerular vasculature embraced by podocytes and supported by mesangial myofibroblasts, which ensure plasma filtration at the podocyte-generated slit diaphragm. With a spectrum of podocyte-expressed gene mutations causing… read more here.

Keywords: derived podocytes; human podocyte; differentiation; podocyte ... See more keywords

WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion

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recommendations! Published in 2017 at "Stem Cell Reports"

DOI: 10.1016/j.stemcr.2017.08.020

Abstract: Summary Wilms' tumor suppressor 1 (WT1) plays an important role in cell proliferation and mesenchymal-epithelial balance in normal development and disease. Here, we show that following podocyte depletion in three experimental models, and in patients… read more here.

Keywords: proliferation migration; podocyte depletion; podocyte; proliferation ... See more keywords

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-07594-z

Abstract: The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria. Studies into human podocytopathies to date have employed… read more here.

Keywords: organoid derived; disease modelling; podocyte; cell ... See more keywords
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Increasing urinary podocyte mRNA excretion and progressive podocyte loss in kidney contribute to the high risk of long-term renal disease caused by preterm birth

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-00130-y

Abstract: Podocyte abnormalities are common mechanism driving the progression of glomerular diseases, which account for most chronic kidney diseases (CKDs). However, the role of podocyte in the mechanism of high-risk long-term CKD caused by prematurity has… read more here.

Keywords: long term; term; podocyte; mrna excretion ... See more keywords

A High-Content Screening Technology for Quantitatively Studying Podocyte Dynamics.

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recommendations! Published in 2017 at "Advances in chronic kidney disease"

DOI: 10.1053/j.ackd.2017.04.001

Abstract: Podocytes form the visceral layer of a kidney glomerulus and express a characteristic octopus-like cellular architecture specialized for the ultrafiltration of blood. The cytoskeletal dynamics and structural elasticity of podocytes rely on the self-organization of… read more here.

Keywords: screening technology; high content; podocyte; content screening ... See more keywords

P1808INHIBITION OF MIR-155 IMPROVES PROGNOSIS IN AN EXPERIMENTAL FSGS MOUSE MODEL BY REGULATING AUTOPHAGY

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recommendations! Published in 2020 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaa142.p1808

Abstract: Focal segmental glomerulosclerosis (FSGS), a podocytopathy, is one of the most common primary glomerular diseases causing end-stage renal disease in children. Its mechanisms remain unclear and the effective treatment lacks. MiR-155 is a typical multifunctional… read more here.

Keywords: p1808inhibition mir; mir 155; 155 improves; model ... See more keywords