Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115246
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Traditional Chinese medicine (TCM) has been applied to diabetic kidney disease (DKD). A large number of animal trials each year focus on TCM for DKD, but the evidence for these preclinical studies is… read more here.
Keywords: medicine; podocyte autophagy; jtbf; kidney ... See more keywords
Vitamin D/vitamin D receptor/Atg16L1 axis maintains podocyte autophagy and survival in diabetic kidney disease.
Sign Up to like & getrecommendations! Published in 2022 at "Renal failure"
DOI: 10.1080/0886022x.2022.2063744
Abstract: OBJECTIVE To investigate the effect of vitamin D/vitamin D receptor (VDR)/Atg16L1 signaling on podocyte autophagy and survival in diabetic nephropathy. METHODS Diabetic rat models were induced by intraperitoneal injection of streptozotocin (STZ) (60 mg/kg) and treated… read more here.
Keywords: autophagy; vitamin vitamin; podocyte autophagy; vitamin receptor ... See more keywords
LncRNA X Inactive Specific Transcript Exerts a Protective Effect on High Glucose-Induced Podocytes by Promoting the Podocyte Autophagy via miR-30d-5p/BECN-1 Axis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Endocrinology"
DOI: 10.1155/2023/3187846
Abstract: Inhibiting podocyte autophagy promotes the development of diabetic nephropathy (DN). This study aims to explore the upstream regulatory mechanism of the autophagy-related gene BECN1 in high glucose (HG)-induced podocytes. C57BL/6 mice were treated with 50 mg/kg… read more here.
Keywords: mir 30d; high glucose; mpc5 cells; podocyte autophagy ... See more keywords
Canagliflozin reverses Th1/Th2 imbalance and promotes podocyte autophagy in rats with membranous nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.993869
Abstract: Idiopathic membranous nephropathy is the main cause of chronic kidney disease (CKD). Studies have shown sodium–glucose co-transporter 2 (SGLT2) inhibitors significantly delay renal outcomes in patients with CKD, but the exact mechanism remains unknown. In… read more here.
Keywords: imbalance; podocyte autophagy; th1 th2; canagliflozin ... See more keywords
[The role of podocyte autophagy and endoplasmic reticulum stress in diabetic kidney disease].
Sign Up to like & getrecommendations! Published in 2022 at "Zhonghua wei zhong bing ji jiu yi xue"
DOI: 10.3760/cma.j.cn121430-20210712-01044
Abstract: Diabetic kidney disease (DKD) is one of the serious complications of diabetes mellitus, and it has become the leading cause of chronic renal failure in China. Podocytes are highly differentiated epithelial cells and are the… read more here.
Keywords: podocyte; endoplasmic reticulum; reticulum stress; podocyte autophagy ... See more keywords