Comprehensively characterizing cellular changes and the expression of THSD7A and PLA2R1 under multiple in vitro models of podocyte injury
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3719
Abstract: The unique morphology and gene expression of podocytes are critical for kidney function, and their abnormalities lead to nephropathies such as diabetic nephropathy and membranous nephropathy. Podocytes cultured in vitro are valuable tools to dissect… read more here.
Keywords: pla2r1; cell; thsd7a; podocyte injury ... See more keywords
Protosappanin‐A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT‐mTOR signaling
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DOI: 10.1002/cbin.11218
Abstract: Protosappanin‐A (PrA) and oleanolic acid (OA), which are important effective ingredients isolated from Caesalpinia sappan L., exhibit therapeutic potential in multiple diseases. This study focused on exploring the mechanisms of PrA and OA function in… read more here.
Keywords: akt; injured podocytes; oleanolic acid; akt mtor ... See more keywords
KCNQ1OT1 inhibition alleviates high glucose-induced podocyte injury by adsorbing miR-23b-3p and regulating Sema3A
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-021-02173-x
Abstract: Diabetic nephropathy (DN), a diabetic complication, is the leading cause of end-stage renal disease. KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), a long non-coding RNA, has been unmasked to participate in the pathogenesis of DN. However,… read more here.
Keywords: apoptosis; mir 23b; proliferation; high glucose ... See more keywords
Knocking down Cabin1 induces glomerular podocyte injury
Sign Up to like & getrecommendations! Published in 2018 at "International Urology and Nephrology"
DOI: 10.1007/s11255-018-1787-z
Abstract: BackgroundPodocyte damage exerts a key role in proteinuria. We have demonstrated that calcineurin-binding protein 1 (Cabin1) upregulated during podocyte injury, yet its function in podocyte is still unclear.MethodsWe established 5/6 nephrectomized rats and angiotensin II… read more here.
Keywords: cabin1; knocking cabin1; podocyte; cabin1 induces ... See more keywords
Liver X receptor activation induces podocyte injury via inhibiting autophagic activity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-020-00737-1
Abstract: Podocyte injury plays a key role in the occurrence and development of kidney diseases. Decreased autophagic activity in podocyte is closely related to its injury and the occurrence of proteinuria. Liver X receptors (LXRs), as… read more here.
Keywords: activation; autophagic activity; injury; lxr activation ... See more keywords
GAP-43 ameliorates Podocyte injury by decreasing nuclear NFATc1 expression
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101145
Abstract: Podocyte injury is sufficient to cause glomerulosclerosis and proteinuria, eventually leading to kidney failure. Previous studies found that podocytes and neurons had similar biological characteristics. Growth-associated protein-43 (GAP-43) is a growth cone protein in neurons,… read more here.
Keywords: gap ameliorates; gap; ameliorates podocyte; expression ... See more keywords
Penehyclidine hydrochloride suppresses inflammation response and reduces podocyte injury in diabetic nephropathy by targeting fibrinogen-like protein 2.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108680
Abstract: BACKGROUND Diabetic nephropathy (DN) is one of the main complications of diabetes. Penehyclidine hydrochloride (PHC) has anti-inflammatory, anti-apoptotic and anti-oxidative stress effects. Nevertheless, whether PHC can be used to prevent podocyte injury has not been… read more here.
Keywords: phc treatment; podocyte injury; diabetic nephropathy; injury ... See more keywords
Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2018.10.032
Abstract: Podocyte injury is the major cause of proteinuria in primary glomerular diseases. Oxidative stress has long been thought to play a role in triggering podocyte damage; however, the underlying mechanism remains poorly understood. Here we… read more here.
Keywords: stress; podocyte injury; wnt catenin; oxidative stress ... See more keywords
LncRNA MALAT1/microRNA let-7f/KLF5 axis regulates podocyte injury in diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118794
Abstract: OBJECTIVE The abnormal expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) has been demonstrated to exert pivotal effects in human diseases. We focused on the functions of metastasis associated lung adenocarcinoma transcript 1 (MALAT1)… read more here.
Keywords: microrna let; pathology; malat1; malat1 microrna ... See more keywords
Elabela protects against podocyte injury in mice with streptozocin-induced diabetes by associating with the PI3K/Akt/mTOR pathway
Sign Up to like & getrecommendations! Published in 2019 at "Peptides"
DOI: 10.1016/j.peptides.2019.04.005
Abstract: Diabetic nephropathy is a common complication of diabetes characterized by an increased rate of protein excretion in urine and kidney function loss. Elabela is a newly discovered peptide whose role in the regulation of diabetes… read more here.
Keywords: akt; protects podocyte; pathway; mice ... See more keywords
Bousigonine A and B, bis- and tri-indole alkaloids from Bousigonia mekongensis and their preventing high glucose-induced podocyte injury activity
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DOI: 10.1016/j.tetlet.2019.151042
Abstract: Abstract Bousigonine A (1), an unprecedented eburnamine-voaphylline type dimeric indole alkaloid, and Bousigonine B (2), the first example of eburnamine-eburnamine-aspidospermine type trimeric indole alkaloid were isolated from Bousigonia mekongensis. Their structures were elucidated mainly by… read more here.
Keywords: bousigonia mekongensis; induced podocyte; preventing high; glucose induced ... See more keywords