Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes
Sign Up to like & getrecommendations! Published in 2019 at "International Urology and Nephrology"
DOI: 10.1007/s11255-019-02074-9
Abstract: PurposePodocytes are terminally differentiated cells lining the Bowman’s capsule. Podocytes are critical for the proper glomerular filtration barrier function. At the same time, autophagy is crucial for maintaining podocyte homeostasis and insufficient autophagy could cause… read more here.
Keywords: podocyte loss; spironolactone alleviates; autophagy podocytes; diabetic nephropathy ... See more keywords
Inhibition of Importin-α-mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.0000000000000150
Abstract: BACKGROUND Nuclear translocation of dendrin is observed in the glomeruli in numerous human renal diseases, but the mechanism remains unknown. This study investigated that mechanism and its consequence in podocytes. METHODS The effect of dendrin… read more here.
Keywords: importin; podocyte loss; loss glomerulosclerosis; glomerulosclerosis ... See more keywords