Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00159-z
Abstract: Crb2 is a cell polarity-related type I transmembrane protein expressed in the apical membrane of podocytes. Knockdown of crb2 causes glomerular permeability defects in zebrafish, and its complete knockout causes embryonic lethality in mice. There… read more here.
Keywords: specific crb2; podocyte specific; mice; crb2 ... See more keywords
Podocyte-specific YAP activation triggers crescentic glomerulonephritis through cross-talk with parietal epithelial cells.
Sign Up to like & getrecommendations! Published in 2025 at "Science translational medicine"
DOI: 10.1126/scitranslmed.adq7825
Abstract: Crescentic glomerulonephritis (cGN) is a severe kidney pathology characterized by the aberrant proliferation of epithelial cells, leading to crescent formation within the Bowman's space. The molecular pathways involved in crescent formation remain poorly understood despite… read more here.
Keywords: podocyte specific; parietal epithelial; yap; activation ... See more keywords
MON-476 Growth Hormone and the Glomerular Podocyte: Studies of Podocyte-Specific Growth Hormone Receptor Gene Deletion in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-mon-476
Abstract: Abstract Previous research has suggested a role for growth hormone (GH) in the development of kidney disease. Evidence of increased glomerular size and sclerosis in bovine GH (bGH) overproducing animals suggests that excess GH action… read more here.
Keywords: growth hormone; mice; podocyte specific;
Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure
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DOI: 10.1371/journal.pone.0229397
Abstract: Obesity can initiate and accelerate the progression of kidney diseases. However, it remains unclear how obesity affects renal dysfunction. Here, we show that a newly generated podocyte-specific tubular sclerosis complex 2 (Tsc2) knockout mouse model… read more here.
Keywords: sclerosis; sclerosis complex; podocyte specific; tsc2 podocyte ... See more keywords
Podocyte specific knockout of the natriuretic peptide clearance receptor is podocyte protective in focal segmental glomerulosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "PLOS One"
DOI: 10.1371/journal.pone.0319424
Abstract: Natriuretic peptides (NPs) bind to glomerular podocytes and attenuate glomerular injury. The beneficial effects of NPs are negatively regulated by the NP clearance receptor (NPRC), which is highly expressed in podocytes. To determine if inhibiting… read more here.
Keywords: podocyte specific; podocyte protective; podocyte; specific knockout ... See more keywords
Podocyte-Specific Expression of the Stress Response Protein REDD1 Is Necessary for Diabetes-Induced Podocytopenia
Sign Up to like & getrecommendations! Published in 2024 at "Diabetes"
DOI: 10.2337/db24-0533
Abstract: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and effective treatment modalities that fully address its molecular etiology are lacking. Prior studies support that the stress response protein REDD1 (regulated in development… read more here.
Keywords: podocyte specific; diabetes induced; protein; redd1 ... See more keywords
318-OR: Podocyte-Specific Expression of REDD1 Promotes Altered Glomerular Pathology and Renal Function Deficits in a Rodent Model of Diabetic Nephropathy
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DOI: 10.2337/db24-318-or
Abstract: Introduction & Objective: The pathogenesis of diabetic nephropathy (DN) is complex and multi-factorial; however, it is well accepted that podocyte injury and death are crucial factors in the development of renal complications. We previously observed… read more here.
Keywords: podocyte specific; function; pathology; redd1 ... See more keywords
Podocyte-specific deletion of miR-146a increases podocyte injury and diabetic kidney disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.897188
Abstract: Diabetic glomerular injury is a major complication of diabetes mellitus and is the leading cause of end stage renal disease (ESRD). Healthy podocytes are essential for glomerular function and health. Injury or loss of these… read more here.
Keywords: disease; mir 146a; podocyte specific; deletion mir ... See more keywords
Membranous Nephropathy Target Antigens Display Podocyte-Specific and Non-Specific Expression in Healthy Kidneys
Sign Up to like & getrecommendations! Published in 2025 at "Genes"
DOI: 10.3390/genes16030241
Abstract: Background/Objectives: Autoimmunity towards podocyte antigens causes membranous nephropathy (MN). Numerous MN target antigens (MNTAgs) have been reported, including PLA2R1, THSD7A, NTNG1, TGFBR3, HTRA1, NDNF, SEMA3B, FAT1, EXT1, CNTN1, NELL1, PCDH7, EXT2, PCSK6, and NCAM1, but… read more here.
Keywords: podocyte specific; membranous nephropathy; display podocyte; podocyte ... See more keywords