Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00159-z
Abstract: Crb2 is a cell polarity-related type I transmembrane protein expressed in the apical membrane of podocytes. Knockdown of crb2 causes glomerular permeability defects in zebrafish, and its complete knockout causes embryonic lethality in mice. There… read more here.
Keywords: specific crb2; podocyte specific; mice; crb2 ... See more keywords
MON-476 Growth Hormone and the Glomerular Podocyte: Studies of Podocyte-Specific Growth Hormone Receptor Gene Deletion in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-mon-476
Abstract: Abstract Previous research has suggested a role for growth hormone (GH) in the development of kidney disease. Evidence of increased glomerular size and sclerosis in bovine GH (bGH) overproducing animals suggests that excess GH action… read more here.
Keywords: growth hormone; mice; podocyte specific;
Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure
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DOI: 10.1371/journal.pone.0229397
Abstract: Obesity can initiate and accelerate the progression of kidney diseases. However, it remains unclear how obesity affects renal dysfunction. Here, we show that a newly generated podocyte-specific tubular sclerosis complex 2 (Tsc2) knockout mouse model… read more here.
Keywords: sclerosis; sclerosis complex; podocyte specific; tsc2 podocyte ... See more keywords
Podocyte-specific deletion of miR-146a increases podocyte injury and diabetic kidney disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.897188
Abstract: Diabetic glomerular injury is a major complication of diabetes mellitus and is the leading cause of end stage renal disease (ESRD). Healthy podocytes are essential for glomerular function and health. Injury or loss of these… read more here.
Keywords: disease; mir 146a; podocyte specific; deletion mir ... See more keywords