In vitro polyploidy induction: changes in morphology, podophyllotoxin biosynthesis, and expression of the related genes in Linum album (Linaceae)
Sign Up to like & getrecommendations! Published in 2017 at "Planta"
DOI: 10.1007/s00425-017-2671-2
Abstract: AbstractMain conclusionInduction of tetraploidy was performed and podophyllotoxin production increased by upregulating the expression level and enzyme activity of genes related to its biosynthesis in tetraploid compared to diploidLinum album. Linum album is a valuable… read more here.
Keywords: biosynthesis; linum album; ptox; podophyllotoxin ... See more keywords
Synthesis and biological evaluation of podophyllotoxin derivatives as selective antitumor agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.05.052
Abstract: To improve podophyllotoxin's cytotoxicity and selective effect, twenty-two podophyllotoxin derivatives had been designed and synthesized. The cytotoxicity of these compounds was evaluated on A549, MCF-7, HepG2 and L-02 cell lines. As a result, most of the… read more here.
Keywords: a549 cells; podophyllotoxin derivatives; podophyllotoxin; antitumor ... See more keywords
Dendrimer-conjugated podophyllotoxin suppresses DENA-induced HCC progression by modulation of inflammatory and fibrogenic factors.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology research"
DOI: 10.1039/c9tx00103d
Abstract: Podophyllotoxin has been explored as an anticancer, antiviral, and antibacterial agent; however, its low water solubility and toxicity limit its use. In this study, the efficacy of a more soluble and less toxic polyamidoamine (PAMAM)… read more here.
Keywords: dendrimer conjugated; fibrogenic factors; dpodo; inflammatory fibrogenic ... See more keywords
Synthesis and biological activity, and molecular modelling studies of potent cytotoxic podophyllotoxin-naphthoquinone compounds
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DOI: 10.1039/d2ra03312g
Abstract: A new approach for the synthesis of podophyllotoxin-naphthoquinone compounds using microwave-assisted three-component reactions is reported in this study. Novel podophyllotoxin-naphthoquinone derivatives with modification on ring E were synthesized. All the synthetic compounds were assessed in… read more here.
Keywords: synthesis biological; podophyllotoxin; naphthoquinone compounds; biological activity ... See more keywords
Organo NHC catalyzed aqueous synthesis of 4β-isoxazole-podophyllotoxins: in vitro anticancer, caspase activation, tubulin polymerization inhibition and molecular docking studies
Sign Up to like & getrecommendations! Published in 2024 at "RSC Advances"
DOI: 10.1039/d4ra04297b
Abstract: We present, for the first time, the organo-N-heterocyclic carbene (NHC) catalyzed 1,3-dipolar cycloaddition of 4β-O-propargyl podophyllotoxin (1) with in situ aromatic nitrile oxides to afford regioselective 4β-isoxazolepodophyllotoxin hybrids (6a–n) in benign aqueous-organic media. Preliminary anticancer… read more here.
Keywords: tubulin; caspase activation; podophyllotoxin; inhibition ... See more keywords
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Xenobiotica"
DOI: 10.1080/00498254.2021.1961920
Abstract: Abstract Podophyllotoxin (POD) is a natural compound with antiviral and anticancer activities. The purpose of the present study was to determine the metabolic map of POD in vitro and in vivo. Mouse and human liver… read more here.
Keywords: podophyllotoxin; drug; map antiviral; pod ... See more keywords
Isolation and Cytotoxic Potency of Endophytic Fungi Associated with Dysosma difformis, a Study for the Novel Resources of Podophyllotoxin
Sign Up to like & getrecommendations! Published in 2022 at "Mycobiology"
DOI: 10.1080/12298093.2022.2126166
Abstract: Abstract Endophytic fungi are promising sources for the production of podophyllotoxin-an important anticancer compound, replacing depleted medical plants. In this study, the endophytes associated with Dysosma difformis-an ethnomedicinal plant species were isolated to explore novel… read more here.
Keywords: podophyllotoxin; cytotoxic potency; dysosma difformis; isolation cytotoxic ... See more keywords
Synthesis, Molecular Docking, and Cytotoxic Evaluation of Fluorinated Podophyllotoxin Derivatives
Sign Up to like & getrecommendations! Published in 2023 at "Natural Product Communications"
DOI: 10.1177/1934578x231153733
Abstract: Objective: The study was conducted to evaluate the in vitro and in silico anticancer activity of fluorinated podophyllotoxin derivatives. Methods: Microwave-assisted multicomponent reactions were carried out in an Anton Paar Microwave Synthetic Reactor Monowave 400… read more here.
Keywords: molecular docking; podophyllotoxin; podophyllotoxin derivatives; cytotoxic ... See more keywords
Synthesis and biological activity evaluation of podophyllotoxin-linked bile acid derivatives as potential anti-liver cancer agents.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.2139/ssrn.4051772
Abstract: Podophyllotoxin's undifferentiated cytotoxicity and poor selectivity limit its clinical application. To improve above disadvantages, conjugation of bile acids with podophyllotoxin could improve cell line selectivity of liver cancer to achieve clinical translation further. Enlightened by… read more here.
Keywords: cell; liver cancer; podophyllotoxin; podophyllotoxin linked ... See more keywords
Podophyllotoxin Alleviates DSS-Induced Ulcerative Colitis via PI3K/AKT Pathway Activation
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DOI: 10.33549/physiolres.935487
Abstract: Summary This study systematically evaluated the therapeutic effects of podophyllotoxin in a DSS-induced mouse model of ulcerative colitis. A total of 374 podophyllotoxin-related targets were identified through database screening, and by intersecting them with 1,741… read more here.
Keywords: podophyllotoxin; dss induced; induced ulcerative; ulcerative colitis ... See more keywords
Target Analysis and Mechanism of Podophyllotoxin in the Treatment of Triple-Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01211
Abstract: Background As the original compound of many podophyllotoxin derivatives, podophyllotoxin has a beneficial antitumor effect. The mechanism of podophyllotoxin activity in triple-negative breast cancer still needs to be explored. Methods We used cell proliferation assay,… read more here.
Keywords: analysis; podophyllotoxin; triple negative; breast cancer ... See more keywords