Synthesis and biological evaluation of podophyllotoxin derivatives as selective antitumor agents.
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DOI: 10.1016/j.ejmech.2018.05.052
Abstract: To improve podophyllotoxin's cytotoxicity and selective effect, twenty-two podophyllotoxin derivatives had been designed and synthesized. The cytotoxicity of these compounds was evaluated on A549, MCF-7, HepG2 and L-02 cell lines. As a result, most of the… read more here.
Keywords: a549 cells; podophyllotoxin derivatives; podophyllotoxin; antitumor ... See more keywords
Synthesis, Molecular Docking, and Cytotoxic Evaluation of Fluorinated Podophyllotoxin Derivatives
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DOI: 10.1177/1934578x231153733
Abstract: Objective: The study was conducted to evaluate the in vitro and in silico anticancer activity of fluorinated podophyllotoxin derivatives. Methods: Microwave-assisted multicomponent reactions were carried out in an Anton Paar Microwave Synthetic Reactor Monowave 400… read more here.
Keywords: molecular docking; podophyllotoxin; podophyllotoxin derivatives; cytotoxic ... See more keywords