Therapeutic efficacy evaluation of radioimmunotherapy with 90Y‐labeled anti‐podoplanin antibody NZ‐12 for mesothelioma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.13979
Abstract: Podoplanin is a type I transmembrane sialomucin‐like glycoprotein that is highly expressed in malignant mesothelioma. The rat‐human chimeric antibody NZ‐12 has high affinity for human podoplanin and antibody‐dependent cellular cytotoxicity and is applicable for radioimmunotherapy… read more here.
Keywords: 90y labeled; mesothelioma; podoplanin; podoplanin antibody ... See more keywords
Influx of podoplanin‐expressing inflammatory macrophages into the genital tract following Chlamydia infection
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12621
Abstract: Genital Chlamydia trachomatis infection remains a major health issue as it causes severe complications including pelvic inflammatory disease, ectopic pregnancy and infertility in females as a result of infection‐associated chronic inflammation. Podoplanin, a transmembrane receptor,… read more here.
Keywords: genital tract; infection; trachomatis; podoplanin expressing ... See more keywords
Immunohistochemical study of CD34 and podoplanin in periodontal disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontal research"
DOI: 10.1111/jre.12635
Abstract: BACKGROUND AND OBJECTIVE The aim of this study was to evaluate the angiogenesis and lymphangiogenesis in gingival tissue biopsy specimens of individuals with clinically healthy gingiva, chronic gingivitis, and chronic periodontitis (n = 30 per clinical condition).… read more here.
Keywords: periodontal disease; podoplanin; study; cd34 podoplanin ... See more keywords
Physiologic and pathophysiologic roles of interaction between C‐type lectin‐like receptor 2 and podoplanin: partners from in utero to adulthood
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DOI: 10.1111/jth.13590
Abstract: A platelet activation receptor, C‐type lectin‐like receptor 2 (CLEC‐2), has been identified as a receptor for a platelet‐activating snake venom, rhodocytin. CLEC‐2 protein is highly expressed in platelets/megakaryocytes, and at lower levels in liver Kupffer… read more here.
Keywords: clec; podoplanin; type lectin; interaction ... See more keywords
Combination of isocitrate dehydrogenase 1 (IDH1) mutation and podoplanin expression in brain tumors identifies patients at high or low risk of venous thromboembolism
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14129
Abstract: Essentials Risk stratification for venous thromboembolism (VTE) in patients with brain tumors is challenging. Patients with IDH1 wildtype and high podoplanin expression have a 6‐month VTE risk of 18.2%. Patients with IDH1 mutation and no… read more here.
Keywords: mutation podoplanin; podoplanin; idh1 mutation; podoplanin expression ... See more keywords
Podoplanin could be a predictive biomarker of the risk of patients with oral leukoplakia to develop oral cancer. A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14378
Abstract: OBJECTIVES To identify and analyze the existing literature on the utility of podoplanin to predict the risk of malignancy development (MD) in patients previously diagnosed with oral leukoplakia (OL). METHODS A systematic review and meta-analysis… read more here.
Keywords: podoplanin; risk; meta analysis; oral leukoplakia ... See more keywords
Podoplanin neutralization improves cardiac remodeling and function after acute myocardial infarction.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.126967
Abstract: Podoplanin, a small mucine-type transmembrane glycoprotein, has been recently shown to be expressed by lymphangiogenic, fibrogenic and mesenchymal progenitor cells in the acutely and chronically infarcted myocardium. Podoplanin binds to CLEC-2, a C-type lectin-like receptor… read more here.
Keywords: podoplanin; myocardial infarction; infarction; function ... See more keywords
Podoplanin expression in primary brain tumors induces platelet aggregation and increases risk of venous thromboembolism.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-06-720714
Abstract: Venous thromboembolism (VTE) is common in patients with brain tumors, and underlying mechanisms are unclear. We hypothesized that podoplanin, a sialomucin-like glycoprotein, increases the risk of VTE in primary brain tumors via its ability to… read more here.
Keywords: aggregation; primary brain; podoplanin; expression ... See more keywords
Podoplanin regulates the migration of mesenchymal stromal cells and their interaction with platelets
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DOI: 10.1242/jcs.222067
Abstract: ABSTRACT Mesenchymal stromal cells (MSCs) upregulate podoplanin at sites of infection, chronic inflammation and cancer. Here, we investigated the functional consequences of podoplanin expression on the migratory potential of MSCs and their interactions with circulating… read more here.
Keywords: mesenchymal stromal; migration mesenchymal; podoplanin; stromal cells ... See more keywords
The Role of Podoplanin in the Immune System and Inflammation
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DOI: 10.2147/jir.s366620
Abstract: Abstract Podoplanin is a small cell-surface mucin-like glycoprotein that participates in multiple physiological and pathological processes. Podoplanin exerts an important function in the immune response and is upregulated in fibroblasts, macrophages, T helper cells, and… read more here.
Keywords: podoplanin; inflammation; immune system; podoplanin immune ... See more keywords
Podoplanin Expression Independently and Jointly with Oral Epithelial Dysplasia Grade Acts as a Potential Biomarker of Malignant Transformation in Oral Leukoplakia
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DOI: 10.3390/biom12050606
Abstract: Our aim was to evaluate the expression of biomarkers, CD44v6, CD147, EGFR, p53, p63, p73, p16, and podoplanin in oral leukoplakias (OL) and to assess their potential for prediction of malignant transformation (MT). We analyzed… read more here.
Keywords: podoplanin; dysplasia grade; malignant transformation; expression ... See more keywords