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   Articles with "podxl" as a keyword



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Podocalyxin‐Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202205451

Abstract: Deciphering signaling mechanisms critical for the extended pluripotent stem cell (EPSC) state and primed pluripotency is necessary for understanding embryonic development. Here, a membrane protein, podocalyxin‐like protein 1 (PODXL) as being essential for extended and… read more here.

Keywords: podxl; pluripotency; like protein; podocalyxin like ... See more keywords
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A cancer-specific anti-podocalyxin monoclonal antibody (60-mG2a-f) exerts antitumor effects in mouse xenograft models of pancreatic carcinoma

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recommendations! Published in 2020 at "Biochemistry and Biophysics Reports"

DOI: 10.1016/j.bbrep.2020.100826

Abstract: Overexpression of podocalyxin (PODXL) is associated with progression, metastasis, and poor outcomes in several cancers. PODXL also plays an important role in the development of normal tissues. For antibody-based therapy to target PODXL-expressing cancers using… read more here.

Keywords: xenograft models; cancer specific; antibody; podxl ... See more keywords
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Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration.

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recommendations! Published in 2017 at "Experimental hematology"

DOI: 10.1016/j.exphem.2017.04.001

Abstract: Podocalyxin (Podxl) is a CD34 orthologue and cell surface sialomucin reported to have roles in renal podocyte diaphragm slit development; vascular cell integrity; and the progression of blood, breast, and prostate cancers. Roles for Podxl… read more here.

Keywords: novel roles; rap1a; stress; podxl ... See more keywords
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Association of serum podocalyxin levels with peripheral arterial disease in patients with type 2 diabetes.

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recommendations! Published in 2019 at "Journal of diabetes and its complications"

DOI: 10.1016/j.jdiacomp.2019.04.003

Abstract: OBJECTIVE Renal podocalyxin is a marker for kidney diseases. Previous studies have shown the expression of serum podocalyxin (s-Podxl) in the endothelial cells of blood vessels. We aimed to investigate the association between s-podxl levels… read more here.

Keywords: podxl levels; pad; pad patients; podxl ... See more keywords
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Additive clinical impact of epidermal growth factor receptor and podocalyxin-like protein expression in pancreatic and periampullary adenocarcinomas

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-67187-z

Abstract: The outcome of periampullary adenocarcinomas remains poor with few treatment options. Podocalyxin-like protein (PODXL) is an anti-adhesive protein, the high expression of which has been shown to confer a poor prognosis in numerous malignancies. A… read more here.

Keywords: like protein; epidermal growth; expression; periampullary adenocarcinomas ... See more keywords
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First identification of PODXL nonsense mutations in autosomal dominant focal segmental glomerulosclerosis.

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recommendations! Published in 2019 at "Clinical science"

DOI: 10.1042/cs20180676

Abstract: Recently, a novel heterozygous missense mutation c.T1421G (p. L474R) in the PODXL gene encoding podocalyxin was identified in an autosomal dominant focal segmental glomerulosclerosis (AD-FSGS) pedigree. However, this PODXL mutation appeared not to impair podocalyxin… read more here.

Keywords: podxl nonsense; nonsense mutations; dominant focal; autosomal dominant ... See more keywords

Podocalyxin molecular characteristics and endometrial expression: high conservation between humans and macaques but divergence in mice

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recommendations! Published in 2022 at "Biology of Reproduction"

DOI: 10.1093/biolre/ioac053

Abstract: Abstract Podocalyxin (PODXL) is a newly identified key negative regulator of human endometrial receptivity, specifically down-regulated in the luminal epithelium at receptivity to permit embryo implantation. Here, we bioinformatically compared the molecular characteristics of PODXL… read more here.

Keywords: podocalyxin; podxl; receptivity; expression ... See more keywords
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Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1101/2022.11.04.515043

Abstract: The glycocalyx component and sialomucin Podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Elevated PODXL expression is also associated with metastasis and poor clinical… read more here.

Keywords: glycocalyx component; podocalyxin; podxl; spatial regulation ... See more keywords
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Podocalyxin Expressed in Antigen Presenting Cells Promotes Interaction With T Cells and Alters Centrosome Translocation to the Contact Site

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.835527

Abstract: Podocalyxin (PODXL), a cell surface sialomucin expressed in diverse types of normal and malignant cells, mediates cellular adhesion to extracellular matrix and cell-to-cell interaction. A previous study reported the expression of PODXL protein on monocytes… read more here.

Keywords: interaction; podocalyxin; podxl; antigen presenting ... See more keywords