Role of poFUT1 and O-fucosylation in placental angiogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioad011
Abstract: Abstract Trophoblast cells are critical to placental angiogenesis in the first trimester of pregnancy. Dysfunction of trophoblast leads to defective vascular remodeling and impaired angiogenesis, which is believed as the major cause of placental insufficiency… read more here.
Keywords: pofut1; fucosylation; angiogenesis; trophoblast cells ... See more keywords
Variant in human POFUT1 reduces enzymatic activity and likely causes a recessive microcephaly, global developmental delay with cardiac and vascular features
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DOI: 10.1093/glycob/cwy014
Abstract: Protein O-fucosyltransferase-1 (POFUT1) adds O-fucose monosaccharides to epidermal growth factor-like (EGF) repeats found on approximately 100 mammalian proteins, including Notch receptors. Haploinsufficiency of POFUT1 has been linked to adult-onset Dowling Degos Disease (DDD) with hyperpigmentation… read more here.
Keywords: developmental delay; likely causes; pofut1; global developmental ... See more keywords
Abstract 904: Mapping the T cell-cold phenotype to the colorectal cancer genome identifies POFUT1 as a driver of tumor T cell inhibition
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-904
Abstract: Colorectal cancer (CRC) patients with T cell-cold tumors experience rapid cancer progression and poor survival. While T cell-enhancing immunotherapies have improved outcomes for a subset of CRC patients, most remain nonresponsive. Therefore, better understanding the… read more here.
Keywords: cancer; cd8; crc; pofut1 ... See more keywords