Dominant TP63 missense variants lead to constitutive activation and premature ovarian insufficiency
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24432
Abstract: Premature ovarian insufficiency (POI) is a leading form of female infertility, characterised by menstrual disturbance and elevated follicle‐stimulating hormone before age 40. It is highly heterogeneous with variants in over 80 genes potentially causative, but… read more here.
Keywords: poi; p63; tp63; missense variants ... See more keywords
Exosomal miRNA‐17‐5p derived from human umbilical cord mesenchymal stem cells improves ovarian function in premature ovarian insufficiency by regulating SIRT7
Sign Up to like & getrecommendations! Published in 2020 at "STEM CELLS"
DOI: 10.1002/stem.3204
Abstract: Premature ovarian insufficiency (POI) is clinically irreversible in women aged over 40 years. Although numerous studies have demonstrated satisfactory outcomes of mesenchymal stem cell therapy, the underlying therapeutic mechanism remains unclear. Exosomes were collected from the… read more here.
Keywords: expression; function; stem; poi ... See more keywords
Premature ovarian insufficiency (POI) and autoimmunity-an update appraisal
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-019-01572-0
Abstract: Primary ovarian insufficiency (POI) represents ovarian dysfunction related to very early aging of the ovaries. While the cause of POI in a majority of clinical cases remains undefined, autoimmunity is responsible for approximately 4–30% of… read more here.
Keywords: poi; poi autoimmunity; ovarian insufficiency; autoimmunity ... See more keywords
Acupuncture for premature ovarian insufficiency: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Acupuncture and Tuina Science"
DOI: 10.1007/s11726-020-1153-4
Abstract: Objective To analyze the effect of acupuncture versus hormone replacement therapy (HRT) for premature ovarian insufficiency (POI). Methods China National Knowledge Infrastructure (CNKI), Wanfang Academic Journal Full-text Database (Wanfang), Chongqing VIP Database (CQVIP), China Biology… read more here.
Keywords: acupuncture; analysis; level; meta ... See more keywords
Diminished Ovarian Reserve Chemotherapy-Induced Mouse Model: A Tool for the Preclinical Assessment of New Therapies for Ovarian Damage
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00191-w
Abstract: Diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI) are primary factors leading to infertility. However, there is a lack of appropriate animal models of DOR usable for assessing new therapeutic strategies. In this study,… read more here.
Keywords: chemotherapy; diminished ovarian; mice; poi ... See more keywords
Serum biomarker analysis in patients with premature ovarian insufficiency.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.154876
Abstract: Premature ovarian insufficiency (POI) is a primary ovarian defect characterized by premature depletion of ovarian follicles before 40 years of age. The disorder has been attributed to various causes, but the study of altered proteins in… read more here.
Keywords: serum; serum biomarker; ovarian insufficiency; premature ovarian ... See more keywords
Investigation of orally delivered carbon monoxide for postoperative ileus
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.07.009
Abstract: ABSTRACT Endogenously produced carbon monoxide (CO) has antioxidant and anti‐inflammatory effects which is why CO has been investigated as a possible therapeutic agent for inflammatory disorders in different body systems, including the gastrointestinal (GI) tract.… read more here.
Keywords: poi; carbon monoxide; postoperative ileus;
New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency.
Sign Up to like & getrecommendations! Published in 2020 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2020.08.005
Abstract: OBJECTIVE To characterize circulating insulin-like factor 3 (INSL3) in different stages of ovarian insufficiency and its role in the evaluation of premature ovarian insufficiency (POI). DESIGN Retrospective cohort study. SETTING University-based center for reproductive medicine.… read more here.
Keywords: insl3; like factor; insulin like; ovarian insufficiency ... See more keywords
The Effect of Bu Shen Huo Xue Tang on Autoimmune Premature Ovarian Insufficiency via Modulation of the Nrf2/Keap1 Signaling Pathway in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.113996
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Bu Shen Huo Xue Tang (BSHXT) is a traditional Chinese medicine formula that is clinically used in the treatment of premature ovarian insufficiency (POI). However, its therapeutic mechanism remains unclear. AIM OF THE… read more here.
Keywords: autoimmune; keap1 signaling; signaling pathway; nrf2 keap1 ... See more keywords
Survey of Canadian PGY-4 and PGY-5 Obstetrics and Gynaecology Residents on Knowledge of and Exposure to Premature Ovarian Insufficiency.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC"
DOI: 10.1016/j.jogc.2018.01.005
Abstract: OBJECTIVES (1) To determine exposure to and general knowledge on premature ovarian insufficiency (POI) among Canadian senior obstetrics and gynaecology residents. (2) To identify opportunity to improve trainee exposure to POI. METHODS Canadian PGY-4 and… read more here.
Keywords: obstetrics gynaecology; gynaecology; obstetrics; pgy ... See more keywords
Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates
Sign Up to like & getrecommendations! Published in 2021 at "Cell Discovery"
DOI: 10.1038/s41421-021-00291-0
Abstract: Premature ovarian insufficiency (POI) is defined as the loss of ovarian activity under the age of 40. Theca cells (TCs) play a vital role during folliculogenesis and TCs dysfunction participate in the pathogenesis of POI.… read more here.
Keywords: transplantation thecal; thecal stem; transplantation; poi ... See more keywords