Fusarium graminearum FgSdhC1 point mutation A78V confers resistance to the succinate dehydrogenase inhibitor pydiflumetofen.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.6795
Abstract: BACKGROUND Fusarium head blight (FHB) caused by Fusarium graminearum complex (Fg) is a devastating disease of cereal crops worldwide. The succinate dehydrogenase inhibitor (SDHI), pydiflumetofen, has been registered for management of FHB in China in… read more here.
Keywords: point mutation; pydiflumetofen; resistance; fusarium graminearum ... See more keywords
Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations
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DOI: 10.1007/s00018-021-04100-5
Abstract: Friedreich Ataxia (FA) is a rare neuro-cardiodegenerative disease caused by mutations in the frataxin (FXN) gene. The most prevalent mutation is a GAA expansion in the first intron of the gene causing decreased frataxin expression.… read more here.
Keywords: friedreich ataxia; decreased frataxin; point mutation; mutation ... See more keywords
Thirty-degree shift in optimum temperature of a thermophilic lipase by a single-point mutation: effect of serine to threonine mutation on structural flexibility
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2950-z
Abstract: In order to understand the molecular basis of cold adaptation, we have used directed evolution to transform a thermophilic lipase LipR1 into its psychrophilic counterpart. A single round of random mutagenesis followed by screening for… read more here.
Keywords: point mutation; flexibility; lipase; thermophilic lipase ... See more keywords
Engineering glutathione S-transferase with a point mutation at conserved F136 residue increases the xenobiotic-metabolizing activity.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.073
Abstract: Glutathione S-transferases (GSTs) are multifunctional enzymes that play major roles in a wide range of biological processes, including cellular detoxification, biosynthesis, metabolism, and transport. The dynamic structural scaffold and diverse functional roles of GSTs make… read more here.
Keywords: conserved f136; engineering; mutation conserved; point mutation ... See more keywords
Investigation of the effects of actinorhodin biosynthetic gene cluster expression and a rpoB point mutation on the metabolome of Streptomyces coelicolor M1146.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2021.01.002
Abstract: The previously reported Streptomyces coelicolor M1146 is commonly used as a host strain for engineering of secondary metabolite production. In this study, absolute quantification of intracellular and extracellular metabolites of M1146 was performed in mid-log… read more here.
Keywords: point mutation; gene; expression; gene cluster ... See more keywords
A Truncating De Novo Point Mutation in a Young Infant with Severe Menkes Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Pediatrics and neonatology"
DOI: 10.1016/j.pedneo.2014.05.008
Abstract: Menkes disease is a rare neurodegenerative disorder caused by mutations in ATP7A gene. Deficiency in copper-dependent enzymes results in the unique kinky hair appearance, neurodegeneration, developmental delay, seizures, failure to thrive and other connective tissue… read more here.
Keywords: point mutation; disease; novo point; menkes disease ... See more keywords
A new point mutation in β2-tubulin confers resistance to carbendazim in Fusarium asiaticum.
Sign Up to like & getrecommendations! Published in 2018 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2017.12.006
Abstract: Resistance to benzimidazole fungicides in many phytopathogenic fungi is caused by specific point mutations in the β-tubulin gene (β-tubulin). However, the mutated locus and genotype of β-tubulin differ among phytopathogenic fungi. To validate the point… read more here.
Keywords: resistance carbendazim; point mutation; point; fusarium asiaticum ... See more keywords
A stress-free strategy to correct point mutations in patient iPS cells
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DOI: 10.1016/j.scr.2021.102332
Abstract: When studying patient specific induced pluripotent stem cells (iPS cells) as a disease model, the ideal control is an isogenic line that has corrected the point mutation, instead of iPS cells from siblings or other… read more here.
Keywords: methodology; point mutation; ips cells; patient ips ... See more keywords
Activity and Point Mutation G699V in PcoORP1 Confer Resistance to Oxathiapiprolin in Phytophthora colocasiae Field Isolates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06707
Abstract: The oxysterol-binding protein inhibitor oxathiapiprolin is a new fungicide for controlling oomycetes diseases. Besides, laboratory mutagenesis oxathiapiprolin-resistance among phytopathogenic oomycetes in the field remains unknown. Here, the sensitivity of 97 P. colocasiae isolates to oxathiapiprolin… read more here.
Keywords: field isolates; point mutation; resistance; oxathiapiprolin ... See more keywords
A single point mutation converts GH84 O-GlcNAc hydrolases into phosphorylases. Experimental and theoretical evidence.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b09655
Abstract: Glycoside hydrolases and phosphorylases are two major classes of enzymes responsible for the cleavage of glycosidic bonds. Here we show that two GH84 O-GlcNAcase enzymes can be converted to efficient phosphorylases by a single point… read more here.
Keywords: mutation converts; point mutation; hydrolases phosphorylases; single point ... See more keywords
C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48157-6
Abstract: Insulin interacts with the insulin receptor, and the activated receptor promotes activity of the phosphoinositide-3 kinase (PI3K) enzyme. A decrease in insulin or insulin-like growth factor 1 (IGF-1) signaling increases the lifespan in mammalian species.… read more here.
Keywords: point mutation; p85 regulatory; phosphoinositide kinase; gene ... See more keywords