Genotoxic effects of topoisomerase poisoning and PARP inhibition on zebrafish embryos.
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DOI: 10.1016/j.dnarep.2019.102772
Abstract: Topoisomerase poisons are known to stabilize covalent enzyme-DNA intermediates forming covalent cleavage complexes, which are highly cytotoxic especially for dividing cells and thus, make topoisomerases targets for cancer therapy. Topoisomerases have been extensively studied in… read more here.
Keywords: embryos; poisoning parp; zebrafish embryos; genotoxic effects ... See more keywords