Single-Molecule Characterization of E. Coli Pol III Core Catalytic Activity
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2778
Abstract: Antibiotic resistance is a growing health problem. Hence new antibiotics and new antibiotic targets are critically needed. Bacterial DNA polymerases are potentially attractive targets for the development of new antibiotics because, while the process of… read more here.
Keywords: pol iii; iii core; dna; core ... See more keywords
Maf1 and Repression of RNA Polymerase III-Mediated Transcription Drive Adipocyte Differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.046
Abstract: SUMMARY RNA polymerase (pol) III transcribes a variety of small untranslated RNAs involved in transcription, RNA processing, and translation. RNA pol III and its components are altered in various human developmental disorders, yet their roles… read more here.
Keywords: iii; transcription; rna; pol iii ... See more keywords
RNA polymerase III initiation on coligo DNA templates containing loops of variable sequence, size and nucleotide chemistry.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.09.001
Abstract: Circularized oligonucleotides, or coligos, were previously found to serve as RNA polymerase III (Pol III) templates in vitro and in human tissue culture cells. Here we randomized the 12-nucleotide larger loop (L-loop) of a well… read more here.
Keywords: initiation; chemistry; coligo; pol iii ... See more keywords
Alcohol-associated cancer and deregulation of Pol III genes.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.09.046
Abstract: Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism… read more here.
Keywords: pol iii; associated cancer; cancer deregulation; alcohol associated ... See more keywords
Functional characterization of Polr3a hypomyelinating leukodystrophy mutations in the S. cerevisiae homolog, RPC160.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.145259
Abstract: Mutations in RNA polymerase III (Pol III) cause hypomeylinating leukodystrophy (HLD) and neurodegeneration in humans. POLR3A and POLR3B, the two largest Pol III subunits, together form the catalytic center and carry the majority of disease… read more here.
Keywords: iii; homolog rpc160; leukodystrophy; cerevisiae homolog ... See more keywords
Snapshots of RNA polymerase III in action - a mini review.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146282
Abstract: RNA polymerase (Pol) III is responsible for the transcription of tRNAs, 5S rRNA, U6 snRNA, and other non-coding RNAs. Transcription factors such as TFIIIA, -B, -C, SNAPc, and Maf1 are required for promoter recognition, promoter… read more here.
Keywords: polymerase iii; rna polymerase; pol iii; snapshots rna ... See more keywords
RNA sequence and structure determinants of Pol III transcriptional termination in human cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166978
Abstract: The precise mechanism of transcription termination of the eukaryotic RNA polymerase III (Pol III) has been a subject of considerable debate. Although previous studies have clearly shown that multiple uracils at the end of RNA… read more here.
Keywords: pol iii; sequence; termination; structure ... See more keywords
Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas
Sign Up to like & getrecommendations! Published in 2019 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-019-0316-7
Abstract: RNA polymerase III (Pol-III) transcribes tRNAs and other small RNAs essential for protein synthesis and cell growth. Pol-III is deregulated during carcinogenesis; however, its role in vivo has not been studied. To address this issue,… read more here.
Keywords: homeostasis; iii; brf1; pol iii ... See more keywords
Yeast PAF1 complex counters the pol III accumulation and replication stress on the tRNA genes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49316-5
Abstract: The RNA polymerase (pol) III transcribes mostly short, house-keeping genes, which produce stable, non-coding RNAs. The tRNAs genes, highly transcribed by pol III in vivo are known replication fork barriers. One of the transcription factors,… read more here.
Keywords: pol iii; transcription; replication; replication stress ... See more keywords
MAF1 is a chronic repressor of RNA polymerase III transcription in the mouse
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68665-0
Abstract: Maf1−/− mice are lean, obesity-resistant and metabolically inefficient. Their increased energy expenditure is thought to be driven by a futile RNA cycle that reprograms metabolism to meet an increased demand for nucleotides stemming from the… read more here.
Keywords: pol iii; maf1; iii transcription; rna polymerase ... See more keywords
Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1405881
Abstract: ABSTRACT RNA polymerase (Pol) III transcribes small untranslated RNAs that are essential for cellular homeostasis and growth. Its activity is regulated by inactivation of tumor suppressor proteins and overexpression of the oncogene c-MYC, but the… read more here.
Keywords: genetic elements; rna polymerase; transformation; pol iii ... See more keywords