Defect of MLH1 expression sensitized esophageal squamous cell carcinoma cells to Polθ inhibitor.
Sign Up to like & getrecommendations! Published in 2025 at "Epigenomics"
DOI: 10.1080/17501911.2025.2579975
Abstract: BACKGROUND A large scale detection of MLH1 methylation is lacking in esophageal cancer. MLH1 is a well-known mismatch repair gene. The mechanism of MLH1 in DNA double strand break (DSB) repair remains unclear. METHODS Esophageal… read more here.
Keywords: methylation; pol inhibitor; cells pol; repair ... See more keywords
Abstract 7119: Clinic-ready Polθ inhibitor SYX1097 suppresses solid tumors in vivo
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DOI: 10.1158/1538-7445.am2024-7119
Abstract: A large fraction of tumors with BRCA1 or BRCA2 mutations only have weak responses to PARP inhibitor (PARPi) treatment, and often develop PARPi resistance. To address these challenges, we have developed SYX1097, a selective and… read more here.
Keywords: pol inhibitor; parpi; syx1097; clinic ready ... See more keywords