POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis.
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DOI: 10.1038/s41556-021-00764-0
Abstract: BRCA2-mutant cells are defective in homologous recombination, making them vulnerable to the inactivation of other pathways for the repair of DNA double-strand breaks (DSBs). This concept can be clinically exploited but is currently limited due… read more here.
Keywords: end joining; mitosis; mediated end; brca2 ... See more keywords