Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant
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DOI: 10.1093/nar/gkaa633
Abstract: Abstract Substitutions in the exonuclease domain of DNA polymerase ϵ cause ultramutated human tumors. Yeast and mouse mimics of the most common variant, P286R, produce mutator effects far exceeding the effect of Polϵ exonuclease deficiency.… read more here.
Keywords: dna polymerase; polymerase; pol; leading strand ... See more keywords