Motif 1 Binding Protein suppresses wingless to promote eye fate in Drosophila
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73891-7
Abstract: The phenomenon of RNA polymerase II (Pol II) pausing at transcription start site (TSS) is one of the key rate-limiting steps in regulating genome-wide gene expression. In Drosophila embryo, Pol II pausing is known to… read more here.
Keywords: m1bp; downregulation; eye fate; pol pausing ... See more keywords
Predictive model of transcriptional elongation control identifies trans regulatory factors from chromatin signatures
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1272
Abstract: Promoter-proximal Polymerase II (Pol II) pausing is a key rate limiting step for gene expression. DNA and RNA-binding trans-acting factors regulating the extent of pausing have been identified. However, we lack a quantitative model of… read more here.
Keywords: transcriptional elongation; promoter proximal; pol pausing; regulatory factors ... See more keywords
RNA polymerase II pausing in development: orchestrating transcription
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DOI: 10.1098/rsob.210220
Abstract: The coordinated regulation of transcriptional networks underpins cellular identity and developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) is a prevalent mechanism by which cells can control and synchronize transcription. Pol II pausing… read more here.
Keywords: development; pol pausing; rna polymerase; transcription ... See more keywords
HSV-1 Infection Induces a Downstream Shift of Promoter-Proximal Pausing for Host Genes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00381-23
Abstract: This study provides a genome-wide analysis of changes in promoter-proximal polymerase II (Pol II) pausing on host genes induced by HSV-1 infection. It shows that standard measures of pausing, i.e., pausing indices, do not properly… read more here.
Keywords: infection; hsv infection; promoter proximal; pol pausing ... See more keywords