Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient RNA polymerase II-dependent transcription
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.211094
Abstract: ABSTRACT This paper describes a novel type of nuclear structure – nuclear lipid islets (NLIs). They are of 40–100 nm with a lipidic interior, and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] molecules comprise a significant part of their surface.… read more here.
Keywords: formation; transcription; phosphatidylinositol bisphosphate; pol transcription ... See more keywords
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005432
Abstract: Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated by RNA polymerase I (Pol I), which… read more here.
Keywords: transcription; rna polymerase; pol transcription;
Regulation of RNA Polymerase I Stability and Function
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DOI: 10.3390/cancers14235776
Abstract: Simple Summary Building ribosomes for cellular protein translation is a massive, energy-consuming undertaking. The process is executed by all cells to replenish the relevant pools of proteins required for cellular functions. Cancer cells are strikingly… read more here.
Keywords: polymerase stability; stability function; transcription; rna polymerase ... See more keywords
Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo
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DOI: 10.7554/elife.28447
Abstract: The Mediator complex has been described as a general transcription factor, but it is unclear if it is essential for Pol II transcription and/or is a required component of the preinitiation complex (PIC) in vivo.… read more here.
Keywords: transcription; vivo; mediator; essential pol ... See more keywords