Probing the mechanisms of two exonuclease domain mutators of DNA polymerase ϵ.
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic acids research"
DOI: 10.1093/nar/gkab1255
Abstract: We report the properties of two mutations in the exonuclease domain of the Saccharomyces cerevisiae DNA polymerase ϵ. One, pol2-Y473F, increases the mutation rate by about 20-fold, similar to the catalytically dead pol2-D290A/E290A mutant. The… read more here.
Keywords: exonuclease domain; dna polymerase; pol2;
BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020199
Abstract: Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a translocation that creates the chimeric transcription factor PAX3-FOXO1 (P3F), which assembles de novo super enhancers to drive high levels of transcription of other core regulatory transcription factors (CRTFs).… read more here.
Keywords: transcription; pol2; bet bromodomain; super enhancers ... See more keywords