Th1 polarization in the tumor microenvironment upregulates the myeloid-derived suppressor-like function of macrophages.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2021.104437
Abstract: Here, we investigated the effect of Th1 polarization in the tumor microenvironment (TME) on tumor-associated macrophage (TAM) maturation and activation. In our immunotherapy mouse model, with a Th1-dominant TME, tumors regressed in all cases, with… read more here.
Keywords: polarization tumor; th1 polarization; tumor microenvironment; myeloid derived ... See more keywords
Polarization of Tumor-Associated Macrophages Promoted by Vitamin C-Loaded Liposomes for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c08446
Abstract: While checkpoint blockade immunotherapy as a promising clinical modality has revolutionized cancer treatment, it is of benefit to only a subset of patients because of the tumor immunosuppressive microenvironment. Herein, we report that the specified… read more here.
Keywords: immunotherapy; cancer; vitamin; polarization tumor ... See more keywords
Anti-PD1 treatment to induce M1 polarization of tumor infiltrating macrophages in a 3D ex vivo system of lung cancer patients.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e23090
Abstract: e23090Background: Nivolumab and pembrolizumab treatment targeting the PD1/PD-L1 axis has demonstrated increased survival benefit in subpopulations of patients with advanced non-small cell lung canc... read more here.
Keywords: polarization tumor; induce polarization; anti pd1; pd1 treatment ... See more keywords
ETV1 inhibition depressed M2 polarization of tumor-associated macrophage and cell process in gastrointestinal stromal tumor via down-regulating PDE3A
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.22-47
Abstract: M2-type polarization of tumor associated-macrophage (TAM) is involved in the malignancy of gastrointestinal stromal tumor (GIST) progression. ETS variant 1 (ETV1) has been previously validated to regulate GIST pathogenesis. Our study intended to explore the… read more here.
Keywords: polarization tumor; depressed polarization; associated macrophage; polarization ... See more keywords