USPIO‐labeling in M1 and M2‐polarized macrophages: An in vitro study using a clinical magnetic resonance scanner
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26360
Abstract: Aim of the study was to evaluate USPIO labeling in different macrophage populations using a clinical 3.0T MR unit with optical and electron microscopy as the gold standard. Human monocytic cell line THP‐1 cells were… read more here.
Keywords: using clinical; p904; study; scanner ... See more keywords
Concurrent stimulation of monocytes with CSF1 and polarizing cytokines reveals phenotypic and functional differences with classical polarized macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0721-383r
Abstract: In atherosclerotic lesions, macrophages are exposed to CSFs and various microenvironmental cues, which ultimately drive their polarization state. We studied the expression of different CSFs in artery specimen and cultured vascular cells and assessed whether… read more here.
Keywords: csm1; concurrent stimulation; polarized macrophages; csm2 ... See more keywords
Exosomes from M2-polarized macrophages relieve oxygen/glucose deprivation/normalization-induced neuronal injury by activating the Nrf2/HO-1 signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2022.109193
Abstract: Stroke is a life-threatening neurological disorder with limited therapeutic efficacy. Previous studies have demonstrated that macrophages play an important role in brain injury after a stroke. However, its underlying mechanism remains unclear and the role… read more here.
Keywords: induced neuronal; injury; oxygen glucose; oxygen ... See more keywords
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.070
Abstract: Endoplasmic reticulum (ER) stress has been shown to play a key role during the initiation and clinical progression of the cardiovascular diseases, such as atherosclerosis. We have recently shown that expression of tissue factor pathway… read more here.
Keywords: inhibitor; tissue factor; pathway; stress ... See more keywords
Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-κB signaling pathway in vascular endothelial cells after traumatic spinal cord injury
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101932
Abstract: Pathologically, blood-spinal-cord-barrier (BSCB) disruption after spinal cord injury (SCI) leads to infiltration of numerous peripheral macrophages into injured areas and accumulation around newborn vessels. Among the leaked macrophages, M1-polarized macrophages are dominant and play a… read more here.
Keywords: vascular endothelial; mir 155; mitochondrial function; endothelial cells ... See more keywords
A new and efficient culture method for porcine bone marrow-derived M1- and M2-polarized macrophages.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2018.04.002
Abstract: BACKGROUND Macrophages play an important role in the innate immune system as part of the mononuclear phagocyte system (MPS). They have a pro-inflammatory signature (M1-polarized macrophages) or anti-inflammatory signature (M2-polarized macrophages) based on expression of… read more here.
Keywords: porcine; culture; polarized macrophages; bone marrow ... See more keywords
Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/7584621
Abstract: Introduction. Macrophages are key players in complex biological processes. In response to environmental signals, macrophages undergo polarization towards a proinflammatory (M1) or anti-inflammatory (M2) phenotype. Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid that acts via… read more here.
Keywords: s1p receptor; expression; s1p; polarized macrophages ... See more keywords
Hypoxia-Driven M2-Polarized Macrophages Facilitate Cancer Aggressiveness and Temozolomide Resistance in Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/1614336
Abstract: Hypoxia-induced M2 phenotypes of tumor associated macrophages (TAMs) promote the development and chemoresistance of multiple types of cancers, including glioblastoma (GBM). However, the detailed molecular mechanisms have not been fully understood. In this study, we… read more here.
Keywords: glioblastoma; polarized macrophages; hypoxia; resistance ... See more keywords
M2 polarized macrophages in bronchoalveolar lavage of lung transplant recipients
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation"
DOI: 10.1183/13993003.congress-2019.pa3357
Abstract: Macrophages are the most abundant cells type in the respiratory tract. They can exhibit different polarization based on different signals received: M1 display cytotoxic and pro-inflammatory activities while M2 pro-fibrotic effects (Suji Eapen et al.… read more here.
Keywords: macrophages bronchoalveolar; lung transplant; transplant recipients; polarized macrophages ... See more keywords
Canine polarized macrophages express distinct functional and transcriptomic profiles
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.988981
Abstract: Macrophage differentiation and function in disease states is highly regulated by the local microenvironment. For example, macrophage exposure to IFN-γ (interferon gamma) initiates the development of inflammatory (M1) macrophages, which acquire anti-tumoral and antimicrobial activity,… read more here.
Keywords: macrophage polarization; canine macrophage; polarized macrophages; canine polarized ... See more keywords
Cellular Carcinogenesis: Role of Polarized Macrophages in Cancer Initiation
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DOI: 10.3390/cancers14112811
Abstract: Simple Summary Inflammation is a hallmark of many cancers. Macrophages are key participants in innate immunity and important drivers of inflammation. When chronically polarized beyond normal homeostatic responses to infection, injury, or aging, macrophages can… read more here.
Keywords: inflammation; cancer; polarized macrophages; carcinogenesis ... See more keywords